Project Grant K23AG084898

Award Date 8/15/24
Completion Date 5/31/29
Dollars Obligated $180K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Durham, NC 27710, USA
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $805,295 to The Leland Stanford Junior University to examine cerebrospinal fluid (CSF) and blood biomarkers to gain insight into postoperative delirium and neurocognitive dysfunction. The goal of the 5-year study is to explore how blood-brain barrier injury, inflammation, and brain injury contribute to delirium and neurocognitive decline after surgery. The researchers will obtain...
This Project Grant from the National Institutes of Health National Institute on Aging provides $4,489,362 to Duke University from September 15, 2022 through August 31, 2025 under the Aging Research program (CFDA 93.866). The grant will fund research to identify mechanisms of blood-brain barrier dysfunction in delirium superimposed on dementia after surgery. Specifically, the researchers will characterize how the postoperative systemic environment impacts the blood-brain barrier using...
This Project Grant award of $243,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a 5-year research program led by Dr. Sara Lahue at the University of California, San Francisco (UCSF). The project aims to characterize the relationship between delirium and biological age in older adults with traumatic brain injury (TBI), and investigate how delirium impacts cognitive and functional outcomes in this population. Key objectives include identifying...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $161,500.00 to investigate the role of perineuronal nets (PNN) in the development of postoperative delirium in aged mice. The research aims to test the hypothesis that changes in PNN and parvalbumin-positive neurons coincide with delirium-like cognitive impairment in aged mice subjected to anesthesia, surgery, and intensive care unit (ICU)-like conditions. The project will also examine whether...
This $1,631,690 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to develop an accurate blood-based biomarker to predict preoperative delirium risk and prognosticate 12-month cognitive decline following delirium in older cardiac surgery patients. Key objectives include: Derive and validate a delirium protein signature using advanced SomaLogic SomaScreen V5.0 proteomics analysis of plasma samples from the ongoing PANDORA clinical trial (900...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,284,161 to The Regents of the University of California, San Francisco to conduct research on perioperative neurocognitive disorders (PNDs) in aging and Alzheimer's disease populations. The key focus is investigating the role of interleukin-6 (IL-6) trans-signaling in increasing vulnerability to PNDs, which can lead to delirium and longer-term cognitive decline in surgical patients. The...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $314,000.00 to investigate the mechanisms by which the complement system, specifically complement C1Q, contributes to synapse loss in Alzheimer's disease (AD). The primary objectives are to: Identify potential C1Q-binding partners at synapses that may facilitate C1Q-mediated synaptic pruning in the presence of pathological tau proteins associated with AD. Determine the effect of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $234,000.00 to the Regents of the University of Michigan to develop immunocytokines for selective, sustained delivery of macrophage colony-stimulating factor (M-CSF) near parenchymal border macrophages in the brain. The goal is to activate these macrophages and improve cerebrospinal fluid dynamics, which has the potential to treat age-related neurodegenerative diseases such as...
This $5,554,915 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research to investigate the role of epigenetics, specifically DNA methylation, in understanding the pathogenesis of postoperative delirium and its association with long-term cognitive decline among elderly patients with dementia. The grant will fund a large study of elderly hip fracture surgery patients to compare genome-wide DNA methylation patterns between those...
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This is a K23 career development award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $180,252 to Duke University for the project "The Role of Cerebrospinal Fluid Complement Activation in Delirium and Post-Intensive Care Unit Long-Term Cognitive Impairment." The award aims to advance the career of Dr. Michael Devinney, a critical care physician-scientist, towards becoming an independently funded researcher focused on discovering mechanisms underlying delirium and its long-term cognitive consequences. The project will leverage a unique biorepository and recruit a cohort of 120 older ICU patients to investigate the role of cerebrospinal fluid complement activation in postoperative delirium, ICU delirium, and post-ICU cognitive impairment. The award will support Dr. Devinney's training in the molecular mechanisms of complement involvement in synaptic dysfunction and Alzheimer's disease, as well as the practical and ethical considerations of ICU research, leading larger studies, and staging Alzheimer's disease. This work seeks to address critical gaps in understanding the drivers of delirium and its sequelae, with the ultimate goal of developing preventative interventions.

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