Project Grant K01AG095307
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a $162,000 Project Grant under the Aging Research program (CFDA 93.866) effective March 1, 2026, through February 28, 2029. This project focuses on identifying and characterizing novel therapy targets in TDP-43 (TAR DNA-binding protein 43) proteinopathies, a class of age-related neurodegenerative diseases affecting millions of patients worldwide. The research addresses a critical gap in...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University $3,188,901 under the Aging Research program (CFDA 93.866) for a four-year project beginning September 1, 2025, and concluding August 31, 2029. This project grant supports research to map amyloid, tau, and neurodegeneration (ATN) biomarkers in relation to neuropsychiatric phenotypes and genotypes across the Alzheimer's disease continuum using machine learning methodologies. The research...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University $150,114 under the Aging Research program (CFDA 93.866) on March 18, 2026, with a completion date of November 30, 2027. This Project Grant supports research investigating the role of brain-engrafted monocyte-derived macrophages (MDMs) in Alzheimer's disease (AD) pathogenesis. The research addresses a critical gap in understanding brain macrophage heterogeneity and the immune mechanisms...
- Federal Grant Award Summary The National Institute on Aging awarded the University of Illinois a $6.67 million Project Grant under the Aging Research program (CFDA 93.866) to develop small molecule ligands targeting pathological tau signaling in Alzheimer's disease and related dementias. The award, effective September 1, 2025, through August 31, 2029, supports the identification and optimization of small molecule inhibitors designed to block the tau phosphatase activating domain (PAD), a toxic...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,459,072 on August 1, 2025, under the Aging Research program (CFDA 93.866) to conduct research on Alzheimer's Disease (AD)-related neurological dysfunction. The research will deliver scientific knowledge and methodological innovations focused on understanding how inhibitory interneurons—specifically parvalbumin (PVALB) and somatostatin (SST) cell types—contribute...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant totaling $593,146 under the Aging Research program (CFDA 93.866) effective January 1, 2026, through November 30, 2030. This research project will investigate mechanisms of activity-dependent transcription and DNA repair in neuronal longevity, with the overarching goal of defining new mechanisms that promote neuronal DNA repair and transcriptional fidelity across the lifespan. The...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $256,746 to The Washington University, effective August 15, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). This K01 Career Development Award funds a rigorous comparative analysis of machine learning-based biological aging "clocks" across three complementary physiological modalities: epigenetic age (DNA methylation patterns), proteomic age (protein...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Regents of the University of California, San Francisco $681,908 under the Aging Research program (CFDA 93.866) on February 15, 2026, with a completion date of November 30, 2030. This project grant supports biomedical research directed at understanding protective mechanisms in tauopathies, a class of neurodegenerative diseases characterized by pathological tau protein aggregation, including Alzheimer's...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $2,957,210 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) on September 15, 2025, for research extending through August 31, 2029, under the Aging Research program (CFDA 93.866). The project, titled "Deciphering the Role of CD44 Astrocytes in Alzheimer's Disease," delivers comprehensive biomedical research aimed at understanding the molecular...
- Federal Grant Award Summary The National Institute on Aging awarded $805,573 to The Regents of the University of California, San Francisco under the Aging Research program (CFDA 93.866) on September 15, 2025, for a project period extending through June 30, 2030. This Project Grant funds research investigating the impact of N6-methyladenosine (M6A) RNA modifications in Alzheimer's disease and related tauopathies. The research will deliver comprehensive characterization of M6A-RNA changes and...
The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $129,876 Project Grant to The Washington University in St. Louis, Missouri, effective June 15, 2026, through March 31, 2031. This award supports research investigating the relationship between tau accumulation, white matter degeneration, and cognitive decline in preclinical Alzheimer disease (AD). The research leverages the Dominantly Inherited Alzheimer Network (DIAN) cohort, which studies autosomal dominant AD (ADAD)—a rare genetic form of AD with known genetic origins and uniform disease progression. By examining ADAD populations, researchers can observe preclinical pathophysiological changes without the confounding influence of age-related comorbidities, generating insights applicable to understanding early disease processes in sporadic late-onset AD. The project deliverables include scientific investigation and analysis of tau tangles measured by positron emission tomography, white matter microstructural integrity, and their relationship to cognitive outcomes in asymptomatic and symptomatic ADAD carriers. Findings from this K01 career development award are expected to advance understanding of neurodegeneration mechanisms during the prolonged preclinical phase of AD and inform hypotheses about early disease processes before symptom manifestation, ultimately contributing to prevention and treatment strategies for Alzheimer disease and related dementias.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $129.9k | 6/16/26 |