Project Grant R01AG092854
- Federal Project Grant Award Summary Rutgers, The State University received $909,876 in funding from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct research on exercise protection of the aging nervous system. The award, issued August 15, 2025, with completion targeted for July 31, 2027, supports a collaborative research initiative designed to elucidate the molecular mechanisms through which exercise provides neuroprotective benefits during aging....
- Federal Project Grant Award Summary Rutgers, The State University received a $431,750 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded June 1, 2025, with completion targeted for May 31, 2027. The award supports research investigating the role of mitochondrial deficits in tauopathy-linked autophagy defects as they relate to Alzheimer's disease pathology. The research focuses on understanding how early mitochondrial abnormalities,...
- Federal Project Grant Award Summary Rutgers The State University of New Jersey, School of Nursing received a $639,838 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded December 15, 2025, with a completion date of November 30, 2030. The grant funds research investigating the role of amyloid precursor protein (APP) metabolites on extracellular vesicle (EV) cargo and function in Alzheimer's disease. The research project will produce scientific...
- Federal Grant Award Summary Rowan University received a $530,469 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective August 15, 2025, with a completion date of July 31, 2028. This research initiative investigates the role of orosomucoid1 in skeletal muscle aging and sarcopenia (age-related loss of muscle mass and function) through an optimized autophagy activity intervention. The research combines pharmacological treatment...
- Federal Project Grant Award Summary Rutgers The State University of New Jersey received a $460,849 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded August 15, 2025, with a completion date of July 31, 2027. The research project investigates the association between Loss of the Y Chromosome (LOY) in hematopoietic cells and genomic instability in aging populations. The grant supports a two-aim study leveraging the Einstein Longevity Cohort biobank to...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rutgers, The State University of New Jersey aims to elucidate the role of the glycoproteome in Alzheimer's disease and related dementias (AD/ADRD). The $795,436 award, beginning April 1, 2025, will identify novel glycopeptiforms related to AD/ADRD pathologies and clinical traits, test if glycopeptiforms link an active lifestyle with brain health, and characterize the genetic architecture of...
- Federal Project Grant Award Summary Oregon Health & Science University has been awarded $471,885 by the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct a two-year research project (Award Date: June 1, 2025; Completion Date: May 31, 2027) investigating the mechanisms by which hyaluronan protects brain vascular endothelial cells from ferroptosis. The research addresses vascular contributions to cognitive impairment and dementia (VCID), the second leading...
- Federal Grant Award Summary The National Institute on Aging awarded a $589,154 Project Grant to the University of Maryland, Baltimore, effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This award supports the development and validation of a normalized cerebrovascular reactivity (NCVR) magnetic resonance imaging technique designed to improve detection of cerebral vascular dysfunction in patients with small-vessel-disease-related cognitive...
- Federal Project Grant Award Summary The National Institute on Aging awarded The Johns Hopkins University a Project Grant of $480,710 (awarded September 5, 2025, with completion by May 31, 2030) under the Aging Research program (CFDA 93.866) to investigate a novel vascular pathway that regulates neuronal survival in neurodegenerative diseases. The research will examine the role of glycerophosphodiester phosphodiesterase 2 (GDE2), a six-transmembrane enzyme in vascular endothelial cells that...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded University of Maryland, Baltimore a $649,766 Project Grant effective March 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This research grant funds a comprehensive five-year investigation examining how hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels mediate olfactory dysfunction in aging and Alzheimer's disease. The project delivers scientific research...
Rutgers, The State University received a $573,035 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) on February 15, 2026, with completion scheduled for January 31, 2031. The award supports fundamental research investigating the cellular mechanisms by which the mechanosensitive ion channel PIEZO1 regulates cerebrospinal fluid (CSF) hydrodynamics and brain-waste clearance. The research deliverables include scientific findings on how pharmacological and genetic manipulation of PIEZO1 influences extracellular matrix remodeling in brain border macrophages, arterial motion dynamics, and the clearance of neurotoxic proteins associated with aging and neurodegenerative disorders such as Alzheimer's disease. The research program employs three integrated aims utilizing mouse genetics, high-resolution multi-photon imaging, and computational modeling. Aim 1 examines whether YODA1 agonist treatment enhances CSF perfusion through PIEZO1 activation in brain border macrophages; Aim 2 uses genetic approaches to directly test PIEZO1's requirement in these cells for maintaining CSF hydrodynamics and waste clearance; and Aim 3 extends this analysis to additional biological contexts. The project directly supports the National Institute on Aging's mission to advance biomedical research on aging processes and age-related diseases, with particular relevance to understanding mechanisms underlying Alzheimer's disease and related dementias.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $573.0k | 2/2/26 |