Project Grant R01AG091365
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $445,625 to Rutgers, The State University to develop an innovative nanotechnology approach to interrupt amyloid-beta (Aβ) aggregation and attenuate neuroinflammation in Alzheimer's disease (AD). The key objectives are to: (1) elucidate how scavenger receptor-targeted nanoparticles can ameliorate Aβ-mediated pathological glial communications, and (2) evaluate the longer-term neuroprotective...
- This $628,000 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how Alzheimer's disease (AD) pathogenesis interferes with synaptic autophagy and evaluate if optimizing synaptic autophagy can be neuroprotective in an AD mouse model. The grant recipient, Rutgers The State University of New Jersey, will utilize primary hippocampal cell cultures and behavioral approaches in mouse models to pursue these research objectives. The project...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rutgers, The State University of New Jersey aims to elucidate the role of the glycoproteome in Alzheimer's disease and related dementias (AD/ADRD). The $795,436 award, beginning April 1, 2025, will identify novel glycopeptiforms related to AD/ADRD pathologies and clinical traits, test if glycopeptiforms link an active lifestyle with brain health, and characterize the genetic architecture of...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $454,271 to Florida Atlantic University to investigate the role of amyloid precursor protein (APP) and cholesterol homeostasis in synaptic dysfunction and neurodegeneration related to Alzheimer's disease (AD). The research aims to use human neurons derived from induced pluripotent stem cells (hiNs) to systematically study how mutations affecting APP distribution, trafficking, and interaction...
- The Johns Hopkins University was awarded a $2,399,582 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) to study extracellular vesicles derived from the brain as potential biomarkers for Alzheimer's disease. The 3-year grant, which begins on September 1, 2023, aims to identify specific cell surface markers and molecular signatures on brain-derived extracellular vesicles that could be used for early disease detection, monitoring, and understanding Alzheimer's...
- This federal Project Grant award of $431,750.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at Rutgers, The State University to investigate the role of mitochondrial deficits in tauopathy-linked autophagy defects for Alzheimer's disease. The research aims to better understand the pathogenic mechanisms of tau protein, a key driver of neurodegeneration in Alzheimer's. The project will explore how early mitochondrial deficits, specifically reduced...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports comprehensive proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The $784,596 grant aims to develop a state-of-the-art proteogenomic pipeline to globally profile disease-associated proteins, including those with amino acid substitutions, alternative isoforms, post-translational modifications, and proteolytic cleavage products. The...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $431,750 aims to isolate and characterize peptide ligands targeting vascular endothelial cells (VECs) in young versus aged mice in vivo and senescent versus non-senescent murine VECs in vitro. The primary objectives are to enhance the understanding of molecular mechanisms and age-related pathologies associated with vascular dysfunction during aging. The project seeks to...
- This Project Grant award of $328,000 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the Alzheimer's Disease Organelle Proteome Task (ADOPT) pilot phase. The interdisciplinary research team, led by Drs. Biao Wang and Danielle Swaney at the University of California, San Francisco, will use a genetic organelle tagging approach to rapidly purify lysosomes from neurons in wild-type and Alzheimer's disease mouse models. A suite of mass spectrometry experiments will then...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $499,883 to Degrome Therapeutics, Inc. to develop small-molecule degraders of the amyloid precursor protein (APP) as novel therapeutics for Alzheimer's disease (AD). The project aims to optimize lead APP degrader compounds to improve their potency, solubility, and blood-brain barrier permeability, with the goal of identifying the most promising candidates for further development and evaluation...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rutgers, The State University of New Jersey provides $639,838.00 to investigate the role of amyloid precursor protein (APP) metabolites on extracellular vesicle cargo and function related to Alzheimer's disease (AD). The key objectives are to: 1) investigate the molecular mechanism of APP-related cargo loading into extracellular vesicles (EVs); 2) test the effect of APP-EV biogenesis on a rat model of tau pathology; and 3) test the effect of APP-EVs on valosin-containing protein (VCP) mutation-induced pathology. This research leverages Rutgers' expertise in AD rat models and EV isolation techniques to address fundamental questions about APP function in the brain. The award period runs from December 2025 to November 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $639.8k | 12/15/25 |