Project Grant R21AG093047
Award Date 8/15/25
Completion Date 7/31/27
Dollars Obligated $461K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
New Jersey, USA
Similar Awards
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $431,132 to the Albert Einstein College of Medicine to conduct research on the loss of the Y chromosome (LOY) and its implications for the aging process. The research aims to ascertain the extent of LOY mosaicism, identify genes associated with heightened LOY risk, and decode the relationship between LOY and aging. The award supports computational and experimental strategies to achieve...
- The National Institute on Aging (NIA) awarded a $422,125 Project Grant under the Aging Research program (CFDA 93.866) to the University of Miami Office of Research Administration - School of Medicine Division. The 2-year grant, effective September 1, 2023, will investigate the relationship between loss of the Y chromosome (LOY) and Alzheimer's disease (AD) pathogenesis. The project aims to 1) examine whole-blood transcriptomic changes in LOY+ individuals, and 2) determine differences in immune...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
- This National Institute on Aging (CFDA 93.866 Aging Research) Project Grant award of $412,500 to the Trustees of Boston University (Boston University Medical Campus) will fund research to investigate the "vicious cycle" between disruption of chromatin architecture, activation of retrotransposable elements (RTEs), and misexpression of CpG island-deficient genes during the aging process. The research aims to validate the mutual activation between chromatin architecture disruption and RTE...
- This Project Grant award of $3,304,237 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a 40-year longitudinal study examining the links between early life adversity, cumulative life stress, and cellular aging in midlife women and their offspring. The study aims to assess which aspects of life course stress, including childhood, midlife, and cumulative stress, are associated with accelerated cellular aging at age 50. The study will repeat assessments of cell aging...
- This federal Project Grant award of $438,625.00 from the National Institute on Aging (CFDA 93.866 Aging Research) to Brown University aims to study how the cellular senescence phenotype changes over time and develop technology to track the duration of cells in senescent states. The key objectives are to (1) examine how the senescence phenotype, including the senescence-associated secretory phenotype (SASP), evolves from early to deeper states, and (2) advance a multi-symbol molecular recorder...
- The Research Foundation of the City University of New York (RFCUNY), acting as the fiscal administrator for the City University of New York (CUNY), has received a $458,510 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866). This award will support the development of a transformative deep learning framework to integrate multi-omics data and elucidate the molecular mechanisms underlying exceptional longevity (EL). The key objectives are to: 1)...
- This federal Project Grant award of $3,445,585 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the molecular mechanisms and genetic factors underlying human ovarian aging. The research aims to advance scientific understanding of how ovarian aging proceeds and its connections to broader women's health outcomes. The award recipient, The Trustees of Columbia University in the City of New York, will utilize single-cell sequencing techniques to...
- This $333,116 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to understand the impact of telomere dysfunction and natural aging on the intestinal stem cell niche. The goal is to examine how aging and acute telomere failure suppress stromal niche support for intestinal stem cells, contributing to intestinal phenotypes associated with aging and telomeropathies like dyskeratosis congenita. The research will utilize a novel mouse...