Project Grant R01AG092770
- Federal Grant Award Summary Boston University Medical Campus received a $686,700 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with completion scheduled for July 31, 2027. The grant supports a two-phase research investigation examining chronic wound stress as a biological catalyst for systemic aging and functional decline. During the R61 phase, researchers will establish and validate a mouse model simulating chronic...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Massachusetts Medical School $460,625 on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct a two-year research project concluding April 30, 2027. This project grant supports biomedical research investigating the role of Mixed Lineage Kinase Domain Like Pseudokinase (MLKL) in platelet-mediated immune responses during respiratory viral infections in older adults. The research...
- Federal Grant Award Summary The National Institute on Aging awarded Massachusetts General Hospital a $629,562 Project Grant (CFDA 93.866: Aging Research) effective August 15, 2025, through July 31, 2030, to conduct biomedical research investigating the role of mechanoaging in intestinal homeostasis deterioration with age. The research project will examine how mechanical stiffening of the intestine contributes to the decline in intestinal epithelial homeostasis and barrier integrity in aging...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $3.1 million Project Grant under the Aging Research program (CFDA 93.866) to the University of Pittsburgh to conduct biomedical research on immune response mechanisms related to persistent DNA damage in aging. The four-year research initiative, which commenced September 1, 2025 and concludes August 31, 2029, focuses on investigating the link between persistent DNA damage and NLRP12 (NOD-Like Receptor 12) expression...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $132,472 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), with an award date of September 4, 2025, and a completion date of May 31, 2027. This grant supports research investigating apoptotic dysregulation across different brain cell types in aging and neurodegenerative diseases, particularly Alzheimer's disease. Principal Investigator Dr. Zintis...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $643,089 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 30, 2025, through August 31, 2026. This research grant supports a comprehensive study examining medication self-administration (MSA) as an early cognitive impairment marker in the Framingham Heart Study cohort. The project will conduct objective MSA assessments on...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Boston Children's Hospital a Project Grant of $132,705.00 (awarded June 15, 2025, with completion by May 31, 2027) under the Aging Research program (CFDA 93.866) to support research addressing hematopoietic clonal dominance during aging. The research investigates metabolic vulnerabilities in hematopoietic stem and progenitor cells (HSPCs) that contribute to age-related decline in blood system function and increased...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the Regents of the University of Michigan a Project Grant totaling $298,419 under the Aging Research program (CFDA 93.866) for the period February 1, 2026 through January 31, 2031. This award funds the development of novel machine learning and statistical methodologies designed to analyze immune system data and enhance understanding of immunosenescence—the age-related decline of immune function—and its connection...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $445,130 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. This research project focuses on elucidating the mechanisms by which Membrane Spanning 4A (MS4A) genes regulate neurodegeneration in Alzheimer's disease and related neurodegenerative disorders, including frontotemporal dementia,...
- Federal Project Grant Award Summary The National Institute on Aging awarded the University of Virginia a $522,167 Project Grant, effective August 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). The award supports research investigating mechanisms of ribosomal DNA (rDNA) instability during aging, with the objective of understanding how genomic instability contributes to the aging process. The research focuses on characterizing the roles of the FOB1 protein and...
The National Institute on Aging (NIA) awarded the University of Massachusetts Medical School a $626,409 Project Grant effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This biomedical research project investigates how aging impairs wound healing through hematopoietic stem cell (HSC) dysfunction and immunosenescence. The research deliverables include scientific characterization of aging-induced changes in immune cell function using single-cell epigenomics technologies, identification of HSC-autonomous mechanisms that drive age-related immune dysfunction, and analysis of oxidative stress pathways that contribute to impaired wound healing in older adults. The project aims to provide foundational knowledge for developing interventions to restore youthful immune function and accelerate wound healing in aging populations. The research will be conducted at the University of Massachusetts Medical School in Worcester, Massachusetts, with three primary research aims focused on determining whether aging impairs wound healing through HSC-autonomous mechanisms, identifying aging-specific oxidative stress in HSCs that drives immune aging, and characterizing epigenetic modifications that regulate immune cell gene expression. The expected outcomes include peer-reviewed publications, novel methodological advances in single-cell epigenomics, and scientific evidence supporting potential therapeutic approaches to reverse age-related immune dysfunction and improve tissue repair capacity in older adults.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $626.4k | 1/28/26 |