Project Grant R61AG096091
- This National Institute on Aging (CFDA 93.866 Aging Research) Project Grant award of $412,500 to the Trustees of Boston University (Boston University Medical Campus) will fund research to investigate the "vicious cycle" between disruption of chromatin architecture, activation of retrotransposable elements (RTEs), and misexpression of CpG island-deficient genes during the aging process. The research aims to validate the mutual activation between chromatin architecture disruption and RTE...
- This $367,577 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to Adepthera LLC aims to develop a regenerative peptide therapy to accelerate pressure ulcer healing. Specifically, the award will fund research to identify an optimal formulation of a self-assembling adrenomedullin (ADM) analog gel that can improve local blood circulation and wound healing in aging and diabetic mouse models. The proposed therapy would be administered weekly or biweekly via...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $449,625 to Trustees of Boston University to explore the role of circular RNAs in aging-related sepsis and organ damage. The research aims to determine the function and mechanisms of an aging-induced circular RNA, circ20033, in promoting pro-inflammatory activation of macrophages and lung inflammation after bacterial infections, particularly in older adults. The two-year project will...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $699,344 to Albert Einstein College of Medicine to investigate the impact of surgical stress on age-related changes and resilience, with a focus on sex differences. The project aims to quantify the spatial, temporal, and sex-dependent effects of surgical stress on aging hallmarks and determine how resilience may modulate these relationships. The 2-year award period runs from September 1, 2025 to...
- The National Institute on Aging (NIA) awarded a $295,923 Project Grant (CFDA 93.866 - Aging Research) to Larix Bioscience LLC to develop novel hormonal therapeutics and study their efficacy with adult stem cells for the treatment of chronic pressure ulcers. The project aims to generate stable, bioactive hormone fusion biologics and evaluate their ability to enhance tissue regeneration in pressure ulcer patients, both alone and in combination with adipose-derived or induced pluripotent stem...
- The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $299,428 Project Grant to WNT Scientific LLC to develop an innovative medical device to treat nonunion fractures in older adults. The device is a biodegradable, controlled-release material designed to promote fracture healing by stimulating angiogenesis (blood vessel formation), which is impaired in elderly patients due to chronic inflammation. The awarded project aims to commercialize this...
- This $629,562 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), located in Boston, MA. The grant will support comprehensive scientific research to investigate the role of mechanical stiffening ("mechanoaging") of the intestine in the deterioration of intestinal homeostasis and barrier integrity with age. The research aims to elucidate the fundamental...
- This $333,116 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to understand the impact of telomere dysfunction and natural aging on the intestinal stem cell niche. The goal is to examine how aging and acute telomere failure suppress stromal niche support for intestinal stem cells, contributing to intestinal phenotypes associated with aging and telomeropathies like dyskeratosis congenita. The research will utilize a novel mouse...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $636,342 Project Grant to Trustees of Boston University (doing business as Boston University Medical Campus) to conduct research on normal and pathological brain aging. The grant, with a performance period from August 1, 2025 to April 30, 2030, will support a multiscale modeling and empirical study of progressive myelin dystrophy, loss of synapses, and neuronal hyperexcitability in...
- This federal Project Grant award of $291,913 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Virscio, Inc., a for-profit research company located in Connecticut. The award is focused on developing epigenetic and senescent biomarkers using non-human primate tissues to advance the understanding of biological aging processes and potential anti-aging strategies. The project aims to create minimally invasive biomarker tools, such as blood and skin-based assays,...
This federal Project Grant award of $686,700.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to investigate the impact of chronic wound stress on systemic aging and functional decline. The research will be conducted in two phases: In the R61 phase, the awardee, Trustees of Boston University (doing business as Boston University Medical Campus), will establish a mouse model to simulate chronic wound stress and assess its effects on aging hallmarks and functional outcomes like frailty and sarcopenia. The R33 phase will then examine how pre-existing frailty exacerbates aging in the context of chronic wounds, and test interventions to mitigate molecular and functional aging. This research aims to establish chronic wound stress as a driver of aging and identify therapeutic targets to improve resilience and functional outcomes for adults with chronic wounds.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $686.7k | 8/12/25 |