Project Grant R01AG090583
- This $333,116 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to understand the impact of telomere dysfunction and natural aging on the intestinal stem cell niche. The goal is to examine how aging and acute telomere failure suppress stromal niche support for intestinal stem cells, contributing to intestinal phenotypes associated with aging and telomeropathies like dyskeratosis congenita. The research will utilize a novel mouse...
- This federal Project Grant award for $831,583 was provided by the National Institute on Aging (CFDA 93.866 Aging Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on "Characterizing Microvascular Impairment in Adults with Elevated Genetic Risk for Alzheimer's Disease." The project aims to elucidate the physiological mechanisms by which the APOE-E4 genetic risk factor contributes to microvascular impairment,...
- This Project Grant award of $387,006 from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to understand how indoles derived from commensal gut bacteria can promote mobility and counteract sarcopenia (age-related muscle wasting) in aging animals. The research aims to determine the mechanisms by which indoles regulate muscle protein homeostasis, mitochondrial function, and other cellular pathways to maintain muscle mass and function during...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $132,705 Project Grant under the Aging Research program (CFDA 93.866) to The Children's Hospital Corporation (doing business as Boston Children's Hospital). The award aims to conduct research on "Targeting Metabolic Vulnerabilities to Restore Balanced Hematopoiesis During Aging," with a project period from June 15, 2025 to May 31, 2027. The research will use single-cell...
- This federal Project Grant award of $459,250.00 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) is focused on investigating the impact of stress and resilience on the longitudinal trajectories of Alzheimer's disease (AD)-related brain pathology and cognitive function. The research aims to elucidate the mechanisms by which stress may predispose individuals to long-term cognitive changes and the development of AD. The awardee, The General Hospital...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $129,330 Project Grant to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on profiling and forecasting individual progression in Alzheimer's disease and related dementias (ADRD). The key objectives of this 5-year project are to: 1) deploy a multi-modal information framework that leverages decades-long in vivo and digital...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $636,342 Project Grant to Trustees of Boston University (doing business as Boston University Medical Campus) to conduct research on normal and pathological brain aging. The grant, with a performance period from August 1, 2025 to April 30, 2030, will support a multiscale modeling and empirical study of progressive myelin dystrophy, loss of synapses, and neuronal hyperexcitability in...
- The General Hospital Corporation, doing business as Massachusetts General Hospital, received a $412,500 project grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to explore serious illness communication between Latino Spanish-speaking older adults and community-based palliative care clinicians. The project aims to address critical gaps in serious illness communication for this population, including clinicians' barriers to initiating these conversations and the...
- This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
- This National Institute on Aging (CFDA 93.866 Aging Research) Project Grant award of $412,500 to the Trustees of Boston University (Boston University Medical Campus) will fund research to investigate the "vicious cycle" between disruption of chromatin architecture, activation of retrotransposable elements (RTEs), and misexpression of CpG island-deficient genes during the aging process. The research aims to validate the mutual activation between chromatin architecture disruption and RTE...
This $629,562 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), located in Boston, MA. The grant will support comprehensive scientific research to investigate the role of mechanical stiffening ("mechanoaging") of the intestine in the deterioration of intestinal homeostasis and barrier integrity with age. The research aims to elucidate the fundamental mechanisms driving age-related inflammation and functional declines. This project aligns with the NIA's mission to advance biomedical and behavioral research on aging, with a focus on understanding and treating Alzheimer's disease and related dementias. The award has a performance period from August 15, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $629.6k | 8/11/25 |