This $446,876 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports a comprehensive spatial sequencing study of age-induced changes in the lung during influenza infection. Researchers at Northwestern University will utilize advanced techniques like single-cell RNA sequencing and spatial sequencing to generate a high-resolution atlas of young and aged lung tissue following...
This federal Project Grant award from the National Institute on Aging's Aging Research Program (CFDA 93.866) totaling $572,333 aims to investigate the mechanisms underlying host-virus interactions in the aged population. The grant supports research to: 1) Determine how modulation of host metabolism in older individuals aids in survival of viral infection, and 2) Examine how the aged organism's physiological environment impacts the evolution of RNA virus pathogenicity. Key methods include...
This $586,250 Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports research to investigate how distinct age-associated B cell subsets can protect the aged population from influenza. The primary focus is on understanding the potential of "age-associated B cells" (ABC) to respond to influenza infection and generate antibody-secreting cells, B...
This $528,011 Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the age-related loss of immune resilience during severe respiratory viral infections like COVID-19. The project, led by New York University School of Medicine, will use host transcriptomic approaches to identify immune response patterns that contribute to poor outcomes in older patients with respiratory viral infections. This includes analyzing lower airway and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $794,341 will support research to investigate the mechanistic roles of cellular senescence and blood-brain barrier dysfunction in mediating pathogen-induced progression of Alzheimer's disease. The research will leverage experimental mouse models, molecular characterization of endogenous retrovirus RNA sensing, and human induced pluripotent stem cell (iPSC) models. Key objectives...
This Project Grant award of $158,918 from the National Institute on Aging (CFDA 93.866 Aging Research) will support Vanderbilt University's research into the effects of lifestyle on immune function and molecular aging across different populations. The study will use a multi-omic approach to characterize age-related changes in gene expression, DNA methylation, and clonal hematopoiesis in subsistence-level groups like the Tsimane, Turkana, and Orang Asli, as well as urban populations in the U.S....
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $601,677 to the University of Massachusetts (UMass) from May 1, 2025 to February 28, 2029. The research aims to characterize the formation and biological properties of immune complexes composed of platelet factor 4 (PF4) and antibodies that trigger a rare but dangerous side effect known as vaccine-induced immune thrombotic...
The federal Project Grant award R01AG090337, provided by the National Institute on Aging's Aging Research program (CFDA 93.866), supports research into the cellular and molecular mechanisms underlying the development of chronic lung conditions following respiratory viral infections, including SARS-CoV-2. The $639,740 award, with a performance period from December 2024 to November 2029, will fund studies exploring the hypothesis that targeting the NAD+ ectoenzyme CD38 could mitigate...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) is funding research to define the roles of platelets and macrophages in the healing of abdominal aortic aneurysms (AAA). The $445,500 award, with a performance period from August 2024 to July 2026, will be used by the University of Cincinnati to study how platelet-leukocyte interactions and cross-talk can support regenerative tissue repair and healing of cardiovascular damage...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) in the amount of $448,270 supports research on the role of alveolar type II (ATII) cell senescence in the pathogenesis of influenza in aging populations. The Ohio State University will conduct this 2-year research project aimed at defining the effects of aging, influenza virus infection, and a potential therapeutic treatment (CDP-choline) on ATII cell function, energy metabolism, and...