Project Grant R01AG092732

Award Date 6/17/25
Completion Date 4/30/30
Dollars Obligated $794K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
California, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to develop treatments to remove deleterious mitochondrial DNA (mtDNA) mutations that contribute to aging and age-related diseases. The $146,922 award supports research at the University of Southern California to use genetic and molecular biology tools, along with sequencing techniques, to purge mammalian cells of mtDNA molecules carrying harmful mutations. The project will leverage a cell line...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to improve understanding of the role of genetic variation in mitochondrial-nuclear dynamics and their impact on organismal health. The $399,766 award, effective January 1, 2025 through December 31, 2026, will leverage specific populations of threespine stickleback fish to study how the nuclear genome evolves and adapts to maintain mitochondrial genome variation. The project will fill...
This $2,010,291 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to The Johns Hopkins University. The grant aims to leverage whole-genome sequencing, metabolomics, and proteomics data to identify novel biomarkers and causal relationships between mitochondrial function and aging-related diseases, including all-cause mortality, cardiovascular disease, and frailty. The research will first identify plasma metabolites...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $173,788 to the University of California, Los Angeles (UCLA) to conduct a 5-year research program focused on understanding mitochondrial genome mutations that contribute to human tissue aging, with a specific focus on skin tissue. The key objectives of the research are to: 1) map and determine the tissue specificity of mitochondrial DNA (mtDNA) mutations in aged skin, 2) quantify mtDNA...
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $793,777 to the J. David Gladstone Institutes to conduct research on the impact of mitochondrial genome architecture on the accumulation of somatic mitochondrial DNA (mtDNA) mutations and their role in cellular aging and age-related degenerative diseases. The study will utilize long-read sequencing approaches to quantify accessibility, mutations, and damage along individual mtDNA molecules, and perform mechanistic work in cultured human cells to understand the role of mtDNA compaction in protection against various stressors. The research also aims to define the consistency of mtDNA form across cell types and age in vivo, with the goal of unveiling new avenues for therapeutic intervention to mitigate aging and related diseases. The award period is from June 17, 2025 to April 30, 2030.

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