The University of Kansas Center for Research Inc. was awarded a $399,766 Project Grant by the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct research on understanding the relationship between mitochondrial and nuclear genome variation, and their impact on mitochondrial dysfunction and disease. The research leverages stickleback fish populations that exhibit exceptional mitogenomic diversity, providing a unique model system to study compensatory mechanisms the nuclear genome uses to maintain compatibility with varying mitochondrial genomes across different environmental contexts. The project aims to provide critical insights into the dynamics of mito-nuclear interactions and their implications for age-related diseases. This work builds on the Center's extensive expertise in areas such as genetics, evolutionary biology, and mitochondrial biology, and will involve analyzing publicly available sequencing data and preserved specimens.
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