Project Grant R01AG092718
- Federal Project Grant Award Summary Vanderbilt University Medical Center received $1,469,914 in project grant funding from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period January 1, 2026 through December 31, 2030. The award supports research titled "Probing Mechanistic Links Between Endothelial Aging and Dementia," which develops and applies a novel human induced pluripotent stem cell-endothelial cell (hiPSC-EC) model to investigate the...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $242,489 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective September 2, 2025, with a completion date of May 31, 2030. The award supports research to identify the proteomic signature associated with dual decline—the concurrent deterioration of gait and cognition in older adults—using plasma proteomics analysis and longitudinal clinical assessments. The research...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $3.15 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 1, 2025, with completion targeted for June 30, 2030. The research initiative investigates the relationship between serum psychotropic drug levels, cytochrome P450 (CYP) metabolizer status, and delirium duration in older hospitalized patients. The project employs liquid...
- Federal Grant Award Summary The National Institute on Aging awarded The Trustees of Columbia University in the City of New York a $690,865 Project Grant (CFDA 93.866 - Aging Research) effective January 15, 2026, with completion targeted for December 31, 2030. This award supports a comprehensive research initiative examining the mitochondrial and energetic underpinnings of resilience in human aging. The research leverages two unique human datasets—the MISBIE Study (which includes patients with...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $149,889 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025, with completion targeted for May 31, 2030. This research initiative will develop and validate deep learning (DL) and artificial intelligence (AI) approaches to identify epigenetic factors associated with early-stage osteoporosis and osteopenia through analysis of computed...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the Broad Institute of MIT and Harvard a Project Grant of $610,836 under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through May 31, 2030. This award supports research on genetic dissection of mitonuclear interactions in aging and neurodegenerative disease. The research will leverage two technological advances—mitochondrial DNA (mtDNA) editing using DDCBE base editors and biobank-scale...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $555,501 to the University of Kansas Medical Center Research Institute, Inc. on September 15, 2025, under the Aging Research program (CFDA 93.866) to conduct a five-year Project Grant investigation into mitochondria-nuclear communication mechanisms in Alzheimer's disease. The research will deliver scientific findings examining how mitochondrial dysfunction leads to increased glycolysis and lactate production, which...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $3.53 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2029. The award supports a comprehensive four-year research initiative to identify sex-specific genetic drivers of cerebrovascular disease (CVD) in Alzheimer's disease (AD) affected brains. The research team will conduct genome-wide association analyses...
- Project Grant Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $322,000 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion scheduled for January 31, 2028. This R03 grant funds research investigating the crosstalk between mitochondrial dysfunction and synaptic vulnerability in Alzheimer's disease (AD), with particular focus on the entorhinal cortex-hippocampus circuit....
- Federal Project Grant Award Summary The National Institute on Aging awarded the University of Virginia a $522,167 Project Grant, effective August 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). The award supports research investigating mechanisms of ribosomal DNA (rDNA) instability during aging, with the objective of understanding how genomic instability contributes to the aging process. The research focuses on characterizing the roles of the FOB1 protein and...
Vanderbilt University received a $482.8K Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research) effective February 1, 2026, through January 31, 2031, to conduct research on sphingolipid-dependent remodeling of mitochondria in aging cells. The research project will deliver scientific findings and methodological advances addressing the mechanisms by which sphingolipid accumulation contributes to age-associated mitochondrial dysfunction. Through three coordinated research aims employing live cell imaging, genetic approaches, and quantitative mass spectrometry analysis across complementary aging models, the project will produce: (1) mechanistic insights into sphingolipid-dependent changes in mitochondrial morphology and strategies for restoring mitochondrial function; (2) characterization of mitochondrial remodeling mechanisms during oxidative stress; and (3) definition of relationships between sphingolipid metabolism and mitochondrial stress responses in aging cells. This collaborative research initiative is designed to advance understanding of fundamental aging biology with potential implications for promoting longevity and healthspan through targeted interventions at inter-organelle lipid transfer junctions. Findings from this National Institute on Aging-supported project will contribute to the broader knowledge base on age-related mitochondrial decline and may inform future therapeutic strategies to prevent or reverse age-associated cellular dysfunction.Federal Project Grant Award Summary