Project Grant R01AG094871
Award Date 9/1/25
Completion Date 8/31/30
Dollars Obligated $772K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Missouri, USA
Similar Awards
- This federal Project Grant award of $2,631,670 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research initiative at The Washington University to investigate age-related deficits in episodic memory. The project aims to determine how aging distinctly affects the content and structure of memory representations, and how this relates to dysfunction in different brain networks based on susceptibility to Alzheimer's disease pathology. The research will utilize plasma...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $705,385 to Northeastern University to conduct a large-scale study investigating mediators and moderators of executive function training in older adults. The study aims to improve the rigor and reproducibility of research on cognitive plasticity in older adults, many of whom are at risk for Alzheimer's disease and related dementias. The study will collect data from 1,250 older adults aged 60+ to...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) in the amount of $665,118 supports a study to examine the neural mechanisms underlying the benefits of aerobic exercise for advanced Parkinson's disease (PD) patients with deep brain stimulation (DBS) implants. The research will enroll 51 advanced PD patients with DBS to assess the impacts of voluntary and forced aerobic exercise on motor, cognitive, and dual-task performance. Neural activity...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $670,600 to The Johns Hopkins University to conduct research on the role of microglia in Parkinson's disease (PD) cognitive and motor impairment. The research aims to better understand the relationship between a microglial-specific radioligand, [11C]CPPC, and the severity of...
- This $1,707,089 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research by Northwestern University to investigate synergistic approaches for enhancing endoplasmic reticulum (ER) proteostasis, protein trafficking, and lysosomal activity as potential treatments for dementia with Lewy bodies and Parkinson's disease-dementia. The research will use patient-derived induced pluripotent stem cell neuron models and mouse models to test the effects of...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop analytical approaches to determine how zinc's (Zn2+) ability to modulate dopamine (DA) release and uptake is affected in Alzheimer's disease (AD) and Parkinson's disease (PD). The total award of $661,537 was made on December 15, 2024 to the University of Kansas Center for Research Inc. The project will utilize fast-scan cyclic voltammetry combined with light-induced release of...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $405,045.00 to the University of Florida to study the neural mechanisms underlying locomotor adaptation deficits and freezing of gait in Parkinson's disease (PD) patients. The project aims to understand how abnormal neural oscillations in the globus pallidus internus (GPI) disrupt the regulation of human walking in PD. The research will utilize a split-belt treadmill paradigm and record local...
- This federal Project Grant award of $203,278.00, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund research to understand the behavioral and neurobiological mechanisms underlying age-related shifts in motivation and their impact on daily life activity participation in older adults. The research will employ a multilevel, multimodal approach, utilizing behavioral, psychophysiological, neuroimaging, and naturalistic assessment methods to...
- This Project Grant award, totaling $684,451, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The primary objective is to develop an integrative machine learning pipeline to identify Parkinson's disease (PD) progression subtypes and potential drug targets through analysis of longitudinal clinical, transcriptomic, and neuroimaging data. Key...
- This Project Grant award of $1,851,569 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research investigating the relationship between early brain development and later neurodegeneration associated with Alzheimer's disease (AD). The research aims to test two key hypotheses: 1) brain regions with high plasticity in early life are more susceptible to pathological changes later in life, and 2) the detrimental impact of social determinants of health (e.g., low...