This Project Grant award of $1,006,653 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Posit Science Corp. supports the "IMPROVING NEUROLOGICAL HEALTH WITH ACETYLCHOLINE VIA NEUROPLASTICITY-BASED COMPUTERIZED EXERCISE IN MILD COGNITIVE IMPAIRMENT (INHANCE-MCI)" program. The project aims to deploy a computerized cognitive training program that integrates validated exercises to potentially reduce the long-term risk of dementia onset in individuals with mild...
The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $344,164 project grant to Northwestern University to develop "M4: Modules on Advanced Methodology When Modeling Multinational Data." The primary objectives are to: 1) create a training program in large-scale data analysis for the next generation of researchers, 2) instruct trainees on protective behavioral and social factors related to Alzheimer's disease and related dementias...
This federal Project Grant award of $441,612 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Trustees of Boston University (Boston University Medical Campus) supports research to evaluate the use of digital cognitive measures, such as digital pen tasks and voice recordings, to monitor early cognitive decline in relation to modifiable Alzheimer's disease risk factors. The project aims to leverage the Framingham Heart Study's longitudinal data on digital cognitive...
The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $636,342 Project Grant to Trustees of Boston University (doing business as Boston University Medical Campus) to conduct research on normal and pathological brain aging. The grant, with a performance period from August 1, 2025 to April 30, 2030, will support a multiscale modeling and empirical study of progressive myelin dystrophy, loss of synapses, and neuronal hyperexcitability in...
This federal Project Grant award of $423,500 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the behavioral, electrophysiological, and pupil-based rhythms of attention and memory in young and older adults. The project will examine attention and memory performance concurrently with electroencephalography (EEG) and pupillometry, with a sample of 75 young and 75 cognitively unimpaired older adults screened for Alzheimer's disease pathology. The goal is...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $167,940 project grant to The Children's Hospital Corporation (Boston Children's Hospital) to elucidate the neuronal mechanisms underlying cognitive resilience to Alzheimer's disease. The project, awarded on August 15, 2025, aims to (1) determine if the MEF2 transcription factors mediate survival of specific neuronal subtypes vulnerable to Alzheimer's pathology, (2) assess whether...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Trustees of Boston University, doing business as Boston University Medical Campus, provides $2,330,859.00 in funding to study age-related changes in brain network connectivity and their relationship to cognitive decline. The 3-year project aims to use multimodal neuroimaging, single-cell transcriptomics, electrophysiology, and neural tract-tracing in a rhesus monkey model to delineate how...
This federal Project Grant award of $203,278.00, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund research to understand the behavioral and neurobiological mechanisms underlying age-related shifts in motivation and their impact on daily life activity participation in older adults. The research will employ a multilevel, multimodal approach, utilizing behavioral, psychophysiological, neuroimaging, and naturalistic assessment methods to...
This federal Project Grant award of $2,631,670 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research initiative at The Washington University to investigate age-related deficits in episodic memory. The project aims to determine how aging distinctly affects the content and structure of memory representations, and how this relates to dysfunction in different brain networks based on susceptibility to Alzheimer's disease pathology. The research will utilize plasma...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $302,960 to Harvard T.H. Chan School of Public Health to conduct research on identifying individuals who would benefit most from intensive blood pressure control for preventing cognitive decline and dementia, as well as those at risk of serious adverse events. The research will utilize advanced statistical methods and pooled data from multiple large-scale randomized trials to detect...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $705,385 to Northeastern University to conduct a large-scale study investigating mediators and moderators of executive function training in older adults. The study aims to improve the rigor and reproducibility of research on cognitive plasticity in older adults, many of whom are at risk for Alzheimer's disease and related dementias. The study will collect data from 1,250 older adults aged 60+ to examine how different training approaches (single vs. multicomponent, standard vs. gamified, standard vs. coached) impact adherence, cognitive outcomes, everyday functioning, and individual characteristics. This comprehensive research effort is intended to address critical gaps in the current evidence and provide insights to guide more effective cognitive training interventions for older adult populations. The award period runs from Apr 1, 2025 to Aug 31, 2030.