This Project Grant award, valued at $112,158 and funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify neurophysiological markers of depression in Parkinson's disease (PD) and determine their relationship to the efficacy of deep brain stimulation (DBS) therapy.
The research led by the University of Florida aims to use multimodal approaches, including neural recordings, neuroimaging, and computational modeling, to investigate basal ganglia network activity associated with depression in PD patients and understand how DBS targeting the globus pallidus internus or subthalamic nucleus may impact depression symptoms. The findings from this project are expected to inform the development of neurophysiology and network-guided neuromodulation therapies for managing depression in Parkinson's disease.
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