This Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,275,512 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the impact of progranulin species on TDP-43 proteolysis and pathobiology in neurodegenerative disorders such as Alzheimer's disease, frontotemporal dementia, and limbic-predominant, age-associated TDP-43 encephalopathy. The research aims to determine how progranulin species contribute to TDP-43...
This $1,157,896 Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research at Brown University focused on elucidating the mechanistic basis of transketolase-mediated suppression of neurodegeneration in amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). The grantee will study multiple models of ALS/FTD using Drosophila genetics and analyze molecular readouts such as redox state, autophagy,...
This three-year, $5.782 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will support research into single-cell characterization of frontotemporal lobar degeneration caused by mutations in the progranulin gene. The University of California, San Francisco will map the transcriptome and gene regulatory networks that define glial pathology and neuronal vulnerability in the frontal cortex and thalamus of progranulin-deficient...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $921,822 to Yale University to elucidate the molecular mechanisms by which the protein kinase TBK1 helps match lysosome function to cellular demand in neurodegenerative diseases. The research aims to define a new pathway in which TBK1 signals at the lysosome surface, including how the C9ORF72 protein regulates this lysosomal pool of TBK1 and other activators of TBK1 at lysosomes such as...
This Project Grant award of $816,661 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a comprehensive research project entitled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics". The research, conducted by The Regents of the University of California, San Francisco, aims to systematically elucidate the molecular and cellular mechanisms by which pathological tau drives neurodegeneration in Alzheimer's disease...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,376 to The Regents of the University of California, San Francisco to explore the molecular mechanisms underlying the heterogeneity of Alzheimer's disease and related dementias. The project aims to identify key genes that mediate the selective vulnerability of brain regions to distinct pathological protein conformers, such as tau and alpha-synuclein, using a novel computational modeling...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
This $630,496 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the J. David Gladstone Institutes in San Francisco, CA supports a research project titled "Proteostasis, Neuroinflammation and Neurodegeneration in Frontotemporal Dementia". The project aims to investigate the underlying mechanisms of proteostasis dysfunction and the link between glial cell activation, inflammation, and neurodegeneration in frontotemporal dementia caused by GRN...
This federal Project Grant award of $1,076,760 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand the genetic underpinnings and disease mechanisms of frontotemporal lobar degeneration (FTLD), a group of neurodegenerative disorders affecting personality, cognition, and communication. The key products and services to be delivered under this 5-year award include: 1) Developing a novel "humanized" mouse model of FTLD by transplanting...
This Project Grant award of $328,000 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the Alzheimer's Disease Organelle Proteome Task (ADOPT) pilot phase. The interdisciplinary research team, led by Drs. Biao Wang and Danielle Swaney at the University of California, San Francisco, will use a genetic organelle tagging approach to rapidly purify lysosomes from neurons in wild-type and Alzheimer's disease mouse models. A suite of mass spectrometry experiments will then...
This $3,841,367 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to better understand the role of the TBK1 protein kinase and associated autophagy pathways in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The University of California, San Francisco (UCSF) will use advanced stem cell models and proteomics to: 1) identify novel TBK1 substrates and characterize the effects of TBK1 loss on neural regeneration, 2) define the consequences of the autophagy protein OPTN and its disease variants, and 3) construct protein interaction networks for selective autophagy cargo receptors and their contributions to secretory autophagy. The goal is to comprehensively understand TBK1-associated autophagy pathways in human neurons to support the development of new therapeutic approaches for age-related neurodegeneration.