Project Grant R01AG084672
Award Date
9/30/24
Completion Date
8/31/29
Dollars Obligated
$1.1M
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Belgium
Similar Awards
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $630,496 to the J. David Gladstone Institutes in San Francisco, CA to conduct research on the proteostasis, neuroinflammation, and neurodegeneration mechanisms involved in frontotemporal dementia (FTD) caused by GRN haploinsufficiency. The key objectives are to better define the alterations in proteostasis, autophagy/lysosomal function, and TDP-43 turnover in FTD neurons, microglia, and...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports advanced research into the mechanisms underlying frontotemporal lobar degeneration (FTLD) and related neurodegenerative diseases. The $1,138,538 award, granted on December 15, 2024, enables the research team at Mayo Clinic Jacksonville to investigate key molecular...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $104,164 to Emory University to investigate the interaction between the TMEM106B gene and the C9ORF72 gene, which are both linked to frontotemporal dementia (FTD) and other neurodegenerative disorders. The research aims to determine how the TMEM106B protein interacts with the dipeptide repeat proteins produced by the C9ORF72 gene mutation, and to examine the toxicity of...
This $786,632 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Northwestern University supports comprehensive scientific investigations into the anatomic, pathologic, and molecular signatures of frontotemporal lobar degeneration with transactive response DNA-binding protein type C (FTLD-TDP type C). The five-year grant aims to expand on prior discoveries by the Northwestern Primary Progressive Aphasia Research Program, which has built one of the...
This $305,000 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research at the University of Florida to investigate the effects of GRN gene mutations on motor and language deficits associated with frontotemporal dementia (FTD). The key objectives are to: Examine motor and non-motor behavioral deficits in a mouse model with striatum-specific GRN knockout. Analyze changes in striatal neuron properties, cholinergic interneurons, and...
This three-year, $5.782 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will support research into single-cell characterization of frontotemporal lobar degeneration caused by mutations in the progranulin gene. The University of California, San Francisco will map the transcriptome and gene regulatory networks that define glial pathology and neuronal vulnerability in the frontal cortex and thalamus of progranulin-deficient...
The National Institute on Aging (NIA) awarded a $1,275,512 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to The Regents of the University of California, San Francisco (UCSF) to investigate the impact of progranulin species on the clearance of TDP-43 protein in neurodegenerative disorders such as Alzheimer's disease, frontotemporal dementia, and limbic-predominant age-associated TDP-43 encephalopathy. The 2-year grant, with a start date of June 1, 2025, aims to...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,540,579 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Regenerative Research Foundation. The grant, which runs from June 1, 2025 to May 31, 2027, will fund the development and validation of a novel, cellularly complex 3D human cell model of frontotemporal dementia (FTD) due to mutations in the MAPT gene that encodes tau protein. The model...
This $1,157,896 Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research at Brown University focused on elucidating the mechanistic basis of transketolase-mediated suppression of neurodegeneration in amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). The grantee will study multiple models of ALS/FTD using Drosophila genetics and analyze molecular readouts such as redox state, autophagy,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...