The National Institute on Aging (NIA) awarded a $2,069,215 Project Grant (CFDA 93.866) to Case Western Reserve University (CWRU) to investigate the role of the beta-arrestin2-LMBRD2 cascade in the pathogenesis of alpha-synuclein, a key protein involved in Lewy body diseases like Parkinson's disease and dementia with Lewy bodies. The research aims to elucidate the mechanisms governing the internalization and transmission of pathological alpha-synuclein, which is critical for understanding disease progression. The project will leverage cellular models, animal models, and advanced analytical techniques to validate, dissect, and characterize the beta-arrestin2-LMBRD2 pathway's regulation of alpha-synuclein function, accumulation, transmission, and toxicity. This grant supports comprehensive scientific investigations into the biological, clinical, and sociobehavioral aspects of aging and age-related neurodegenerative conditions.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.1m | 8/5/24 |