The University of Texas Health Science Center at Houston (UTHealth) received a $766,133 Project Grant award from the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The award, effective January 1, 2025, supports a research project to investigate the mechanisms underlying amyloid-related imaging abnormalities (ARIA) that can occur following anti-amyloid immunotherapy for Alzheimer's disease. The key objectives are to:
- Determine the elimination pathways and clearance mechanisms of anti-amyloid antibodies in Alzheimer's disease mouse models.
- Examine how ARIA events develop in Alzheimer's disease mice receiving chronic administration of conformationally distinct anti-amyloid antibodies, and assess the pharmacokinetic/pharmacodynamic relationships.
- Investigate the mechanisms of vascular inflammation that exacerbate amyloid deposition in immunotherapy-treated animals.
The findings from this comprehensive project are expected to provide insights into safely administering anti-amyloid immunotherapy and developing adjunctive treatments to mitigate ARIA risks for Alzheimer's disease patients. The award is scheduled for completion by November 30, 2029.
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