This $894,922 National Institutes of Health National Institute of Neurological Disorders and Stroke project grant supports research at Duquesne University from September 2022 to August 2025 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant funds research to test the hypothesis that myelination is linked to resilience against limbic alpha-synucleinopathy and is modified by microglia/macrophages. Specifically, the university...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA Program 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, will provide $2,280,379 to the Regents of the University of Michigan to develop novel nanobody-based agents that can target pathogenic alpha-synuclein to block its cell-to-cell transmission. The grant aims to characterize these nanobody-based agents and assess their in vitro and in...
This Project Grant award of $414,191 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research by Drexel University investigating the relationship between structural variations in alpha-synuclein (α-syn) protein fibrils and the development of distinct neurodegenerative synucleinopathies such as Lewy body dementia, Parkinson's disease, and multiple system atrophy....
This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...
This $2,069,215 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by Case Western Reserve University to investigate the role of the beta-arrestin2-LMBRD2 pathway in the transmission and toxicity of pathological alpha-synuclein, which is a defining hallmark of Lewy body diseases such as Parkinson's disease and dementia with Lewy bodies. The research will utilize cellular and animal models to study the mechanisms by which beta-arrestin2...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $2,234,905.00 in funding to The University of Iowa to support research aimed at understanding the underlying mechanisms responsible for cognitive fluctuations in Lewy body disorders (LBD). The project will use mouse models to evaluate how the accumulation of...
This federal Project Grant award of $227,205, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the effects of the Parkinson's disease-associated protein LRRK2 on lysosomal function and inflammatory activity in microglia. The research, conducted by Northwestern University, aims to: 1) examine how LRRK2 and the Parkinson's...
This $1,707,089 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research by Northwestern University to investigate synergistic approaches for enhancing endoplasmic reticulum (ER) proteostasis, protein trafficking, and lysosomal activity as potential treatments for dementia with Lewy bodies and Parkinson's disease-dementia. The research will use patient-derived induced pluripotent stem cell neuron models and mouse models to test the effects of...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the role of alpha-synuclein-mediated membrane permeabilization in the spread of alpha-synuclein aggregates related to Parkinson's disease and related dementias. The $406,260 award to Purdue University will leverage fluorescence lifetime imaging microscopy...
This $475,369 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how microglia (the brain's resident macrophages) are programmed by the brain environment following transplantation. The primary awardee, The Trustees of the University of Pennsylvania, will use single-cell RNA and ATAC sequencing to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is funding research on the role of microglia/macrophages in Lewy body disorders. The total award amount is $231,826.00, with a project period from September 17, 2024 to August 31, 2026.
The key objectives of the research are to: 1) identify the neural cell type most likely to harbor alpha-synuclein aggregates and determine if these cells can be engulfed by microglia/macrophages; 2) ascertain how transient depletion and repopulation of microglia/macrophages reduces alpha-synuclein aggregate burden in a mouse model. The research involves experimental work at Duquesne University, with sub-awards to the University of Pittsburgh and the University of Pennsylvania to support specific aspects of the study design, execution, and data analysis.