The National Institutes of Health National Institute on Aging awarded $4,575,712 under the Aging Research program (CFDA 93.866) to The Washington University from May 2022 to April 2025. The award will support research into white matter metabolism in the context of aging, white matter hyperintensities, and Alzheimer's disease. Investigators will apply quantitative positron emission tomography imaging techniques to measure cerebral oxygen consumption, blood flow, oxygen extraction fraction, and...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $476,993 to Yale University to develop new methods for measuring white matter hyperintensities (WMH) using low-field portable MRI (PMRI) technology. The project aims to create both a qualitative WMH grading scale and a quantitative machine learning-based WMH volume...
This $4.8 million project grant from the National Institutes of Health's National Institute on Aging Aging Research program (CFDA 93.866) will fund research into vascular contributors to blood-brain barrier permeability and regional white matter hyperintensity progression in asymptomatic individuals ages 40-50. The Johns Hopkins University will study how periventricular and deep white matter hyperintensities independently progress and influence clinical outcomes, and how increasing blood-brain...
This Project Grant award of $4,361,625.00 from the National Institute on Aging (CFDA 93.866 Aging Research program) supports a multi-institutional effort led by the Washington University to investigate the molecular mechanisms underlying cerebral small vessel disease (CSVD) and vascular contributions to dementia (VCID). The project leverages three key resources: a large collection of cerebrospinal fluid samples, human brain tissue specimens, and advanced neuroimaging analytical pipelines. The...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will develop three new multi-modal atlases based on data from the Human Connectome Project. The $1,554,682 award will: Create a new data-driven atlas of spatially overlapping weighted grey-matter functional networks, 2) Develop a new data-driven atlas of white matter tracts and their corresponding grey matter projection territories, and 3) Complete a semi-automated multi-modal atlas of human brain areas....
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to create an inter-Alzheimer's Disease Research Center (ADRC) set of objectively measured cerebral small vessel disease (SVD) magnetic resonance imaging (MRI) biomarkers from large and diverse clinical cohorts. The $790,491 award will fund the development and validation of novel deep-learning methods to accurately quantify SVD biomarkers, including cerebral microbleeds, white matter...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study examining the use of high-resolution diffusion imaging to assess white matter connectivity and its relation to cognitive function in healthy aging and Alzheimer's disease. The $300,892 award, granted to Duke University, will support a 3-year research project that aims to: Determine if high-resolution diffusion imaging measures of white matter structural connectivity differ from standard...
This Project Grant award, totaling $770,558, was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The award will fund a research project titled "NEUROIMAGE-GENOMIC FINGERPRINTS FOR SUBTYPING AND PREDICTION OF ALZHEIMER'S DISEASE AND RELATED DEMENTIA" at Wake Forest University Health Sciences over a period of 5 years, from July 1, 2025 to March 31, 2030. The project aims to establish connections between Alzheimer's disease-related genomic...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $640,906 to the University of Wisconsin - Madison to elucidate cerebrovascular disease pathways contributing to cognitive decline. The 5-year project, effective June 1, 2025, aims to leverage advanced neuroimaging techniques to characterize dynamic vascular and hemodynamic factors, such as intracranial vascular stiffness and neurovascular flow tone, that may impact brain tissue integrity and...
This Project Grant award of $654,238 from the National Institute on Aging (CFDA 93.866 Aging Research program) supports research to identify the role of senescent neurons in brain aging and Alzheimer's disease and related dementias (ADRD). The primary awardee, the University of Texas Health Science Center at San Antonio, will generate spatial omics data from ADRD brains and mouse models, while the co-investigator team at Washington University will provide expertise in experimental design, data...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports a $3,908,677 research project to disentangle the pathophysiologic heterogeneity of age-related white matter hyperintensities (WMH) using an integrative computational multimodal approach. The project will leverage existing neuroimaging and genetic data from 7 cohorts (N=4,872) and the UK Biobank (N>60,000) to derive distinct, disease-specific WMH spatial patterns using machine learning. These patterns will be examined for biological correlations with vascular and amyloid-related traits, as well as their utility in predicting long-term stroke or dementia outcomes. The project will also integrate molecular quantitative trait loci data into genome-wide association analysis to prioritize causal, functionally active genes contributing to WMH, and perform genomics-driven drug discovery using Mendelian randomization to identify therapeutic targets. Key sub-awardees include researchers from the University of Cincinnati and Washington University in St. Louis who will contribute neuroimaging analysis, genomics expertise, and project oversight.