Project Grant R01AG088690

Award Date 9/1/24
Completion Date 6/30/29
Dollars Obligated $1.3M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
St. Louis, MO 63110, USA
Similar Awards
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,349,483 to Vanderbilt University Medical Center to conduct research on the mechanisms of clonal hematopoiesis (CH) and its impact on aging. The key products and services to be delivered under this award include: Applying a computational method called PACER to estimate CH expansion rates across over 1.6 million individuals to identify genetic factors conferring resilience to CH...
The National Institute on Aging awarded a $1,085,789 Project Grant (CFDA 93.866 - Aging Research) to the Albert Einstein College of Medicine to investigate the relationship between clonal hematopoiesis (CH), aging, and exceptional longevity. The research will study the prevalence and mutational spectrum of CH in centenarians, their offspring, and age/sex-matched controls, examining associations with age-related diseases. The project will also analyze longitudinal CH changes and identify...
This Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,039,644 to President and Fellows of Harvard College to test the hypothesis that age-related perturbations in communication signals between the blood system and other organ systems may drive age-associated dysfunctions across the body. The project will use novel in vivo gene editing techniques to introduce specific blood cell mutations associated with clonal hematopoiesis in aging...
The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $165,080 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Dana-Farber Cancer Institute (DFCI). The grant, which runs from September 1, 2024 to August 31, 2029, will support research to define the relationship between clonal hematopoiesis (CH) and inflammatory disease outcomes. The key goals are to: 1) Characterize the association between CH and...
This Project Grant award, valued at $903,172.00, was issued by the National Institute on Aging under the Aging Research Federal Grant Program (CFDA 93.866). The grant supports a research study examining the role of clonal somatic mutations in microglia and their potential contribution to the development of Alzheimer's disease. The key objectives of the study are to: 1) Identify somatic mutations through re-analysis of existing bulk RNA-sequencing datasets from Alzheimer's disease cohorts,...
This Project Grant award, valued at $1,419,308 and spanning from September 2024 to August 2025, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program. The award supports research to investigate the mechanisms linking persistent DNA damage to the upregulation of the NLRP12 gene, and the functional implications of this link in aging hematopoiesis. The research aims to establish a novel interplay between persistent DNA...
This federal Project Grant award of $570,922.00, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research into the molecular and cellular mechanisms of mutant ASXL1-driven clonal hematopoiesis. The project aims to investigate how the aged bone marrow microenvironment interacts with ASXL1 mutant hematopoietic stem cells to promote their expansion, and determine whether targeting the aged microenvironment and the ASXL1 mutant cells can mitigate this expansion....
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $105,952.00 to Weill Medical College of Cornell University to conduct research on identifying and characterizing clonal expansions in aging and aging-related diseases. The key objectives are to: (1) develop tools for large-scale identification of somatic variants from public data, and (2) apply novel single-cell multi-omic technologies to map genotype-epigenetic relationships and analyze...
The National Institute on Aging (NIA) awarded a $350,001 project grant under its Aging Research Federal Grant Program (CFDA 93.866) to the Icahn School of Medicine at Mount Sinai to conduct research on the role of clonal hematopoiesis in neurodegenerative diseases. The project, titled "Unraveling the Role of Clonal Hematopoiesis in Neurodegenerative Diseases", aims to investigate the associations between different types of clonal hematopoiesis and the risk of Alzheimer's disease,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $302,960 to the Harvard T.H. Chan School of Public Health to conduct research aimed at identifying individuals who would benefit most from intensive blood pressure control for preventing cognitive decline and dementia, as well as those at risk of serious adverse events. The 2-year project will employ advanced statistical methods, including risk score and effect score analyses, to analyze...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $1,276,687 will enable research to improve understanding of the factors that drive the evolution of clonal hematopoiesis (CH) and its association with age-related diseases, including cardiovascular disease and Alzheimer's disease. The primary awardee, Washington University, will leverage existing data from large biobanks and unique cohorts with longitudinal risk factor and biomarker measurements to (1) determine the impact of lifestyle and inherited risk factors on CH evolution, (2) identify the pathways mediating CH evolution, and (3) explore the pathways linking CH to cardiovascular and Alzheimer's disease outcomes. The project includes a sub-award to Harvard T.H. Chan School of Public Health to lead research activities within the Health Professionals Follow-Up Study cohort. This multifaceted study aims to provide critical insights into the mechanisms underlying the relationship between CH, inflammation, and age-related disease development.

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