Project Grant R01AG088657

Award Date 8/15/24
Completion Date 6/30/29
Dollars Obligated $1.3M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Nashville, TN 37203, USA
Similar Awards
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,085,789 to the Albert Einstein College of Medicine to investigate the relationship between clonal hematopoiesis (CH), aging, and exceptional longevity. The key research objectives are to: Determine the prevalence and mutational spectrum of CH and its association with age-related diseases in populations with exceptional longevity, such as centenarians. Analyze longitudinal DNA...
The National Institute on Aging (NIA) awarded a $1,276,687 Project Grant (CFDA 93.866 - Aging Research) to The Washington University in St. Louis to conduct research on the impact of inherited and modifiable risk factors on clonal hematopoiesis (CH) and age-related diseases, including cardiovascular disease and Alzheimer's disease. The research aims to characterize how inherited and lifestyle factors influence CH evolution and identify central pathways driving long-term CH trajectories and...
This Project Grant award of $158,918 from the National Institute on Aging (CFDA 93.866 Aging Research) will support Vanderbilt University's research into the effects of lifestyle on immune function and molecular aging across different populations. The study will use a multi-omic approach to characterize age-related changes in gene expression, DNA methylation, and clonal hematopoiesis in subsistence-level groups like the Tsimane, Turkana, and Orang Asli, as well as urban populations in the U.S....
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $570,922 to the University of Wisconsin-Madison to investigate the molecular and cellular mechanisms by which the ASXL1 gene mutation drives clonal hematopoiesis and expansion of blood cells in older individuals. The key objectives are to: 1) examine how the aged bone marrow microenvironment interacts with ASXL1 mutant hematopoietic stem cells to promote their expansion, and 2) determine...
This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), provides $249,000.00 to The General Hospital Corporation (Massachusetts General Hospital) to conduct a multi-omic investigation of clonal hematopoiesis and associated diseases. The key objectives are to: 1) develop a statistical method to improve discovery and translational insights from proteomics data; 2) examine how the presence of clonal...
This $430,101 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University Medical Center (VUMC) will fund research to identify new genes and variants responsible for telomere shortening, telomere disease risk, and premature aging. The project aims to determine the genetic basis of telomere shortening across diverse tissues, investigate the phenome-wide consequences of telomere length using large-scale biobanks, and identify disease-causing...
The National Institute on Aging (NIA) awarded a $153,696 Project Grant (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University to investigate the developmental origins and functional characteristics of myeloid-biased hematopoietic stem cells (HSCs) in the fetal liver. The research aims to elucidate how lineage biases in HSCs may originate during prenatal development and contribute to age-associated changes in blood cell production. Utilizing advanced techniques such as flow...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $105,952 to Weill Medical College of Cornell University to identify and characterize clonal expansions in aging and aging-related diseases. The key objectives are to: (1) develop tools to identify candidate somatic variants at scale from publicly available data, and (2) apply novel technologies that map genotype to epigenetic phenotype in single cells to analyze multiple tissues from...
The National Institute on Aging (NIA) awarded a $350,001 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to the Icahn School of Medicine at Mount Sinai (ISMMS) for the project "Unraveling the Role of Clonal Hematopoiesis in Neurodegenerative Diseases". The project aims to investigate the associations between different types of clonal hematopoiesis and various neurodegenerative diseases, including Alzheimer's, Parkinson's, Lewy body dementia, and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $719,873 to The Trustees of Columbia University in the City of New York to conduct research on the role of epigenetic deregulation in osteoblasts and its promotion of age-related clonality in hematopoietic cells. The overarching goal is to delineate how epigenetically modified stromal cells and osteoblasts in the bone marrow can support the transformation of IDH1/2-mutant hematopoietic...

This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,349,483 to Vanderbilt University Medical Center (VUMC) to identify mechanisms that confer resilience to clonal hematopoiesis, a condition associated with aging and increased disease risk.

The key objectives are to: 1) Apply a computational method to estimate clonal hematopoiesis expansion rates in over 1.6 million individuals and identify genetic factors conferring resilience; 2) Investigate how circulating proteins, metabolites, and medications modulate clonal hematopoiesis expansion; and 3) Comprehensively assess the impact of clonal hematopoiesis on health outcomes across the human lifespan by analyzing data from the NIH All of Us and Vanderbilt BioVU cohorts.

This multi-year research program involves collaboration with Stanford University, which received a $126,794 sub-award to support the project.

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