Project Grant R01AG088659

Award Date 8/15/24
Completion Date 6/30/29
Dollars Obligated $1.1M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Bronx, NY 10461, USA
Similar Awards
This $1,276,687 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) aims to improve understanding of the factors driving clonal hematopoiesis (CH) evolution and its association with age-related diseases like cardiovascular disease and Alzheimer's disease. The primary awardee, The Washington University, will leverage data from large biobanks and unique cohorts to: (1) determine the impact of lifestyle and inherited risk factors on CH evolution, (2) identify the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,349,483 to Vanderbilt University Medical Center (VUMC) from August 2024 through June 2029 to study the mechanisms of clonal hematopoiesis (CH) and its impact on aging and age-related diseases. The key products and services delivered under this grant include: Applying a computational method called PACER to estimate CH expansion rates in over 1.6 million individuals to identify genetic factors...
This federal Project Grant award of $105,952 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by Weill Medical College of Cornell University to identify and characterize clonal expansions in aging and aging-related diseases. The key objectives are to: (1) develop tools to identify candidate somatic variants at scale from publicly available data, and (2) apply novel technologies that map genotype to epigenetic phenotype in single cells, enabling analysis of...
The National Institutes of Health's National Institute on Aging has awarded a $350,001 Project Grant (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai to investigate the role of clonal hematopoiesis in neurodegenerative diseases. The 1-year project aims to uncover associations between different types of clonal hematopoiesis and conditions like Alzheimer's, Parkinson's, Lewy body dementia, and ALS/FTD. It will leverage genomic, transcriptomic, and functional data to...
The National Institute on Aging (NIA) awarded a $431,132 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Albert Einstein College of Medicine to conduct research on the "Loss of the Y Chromosome and its Implications in Aging". The research aims to explore the genetic factors and mechanisms underlying the relationship between the loss of the Y chromosome (LOY) and the aging process, with the goal of developing a better understanding of age-related...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $570,922.00 to the University of Wisconsin-Madison to investigate the role of the aged bone marrow microenvironment in promoting the expansion of hematopoietic stem cells with ASXL1 mutations, which are associated with an increased risk of blood cancers and other diseases. The research aims to: 1) Examine how the aged bone marrow microenvironment interacts with ASXL1 mutant hematopoietic stem...
This $735,085 Project Grant award from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research at Case Western Reserve University aimed at transforming age-related clonal hematopoiesis (CH) into a more beneficial state. The key focus is on investigating how modulating the Heat Shock Transcription Factor 1 (HSF1) can sustain or enhance hematopoietic stem/progenitor cell (HSPC) self-renewal, maintain balanced lineage...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $153,696 to The Leland Stanford Junior University to investigate the developmental origins and functional characteristics of myeloid-biased hematopoietic stem cells (HSCs) present in the fetal liver. The research aims to elucidate how these myeloid-biased HSCs arise during prenatal development and contribute to age-associated changes in hematopoiesis. The study will employ advanced techniques...
This $430,956 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Duke University aims to identify novel clinical and 'omic risk factors, including telomere length, mitochondrial copy number, and clonal hematopoiesis, for organ dysfunction and early mortality in sickle cell disease (SCD). The project also seeks to identify proteomic and glycoproteomic biomarkers for premature mortality in SCD. By leveraging a large SCD cohort with whole genome sequencing...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $165,080 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Dana-Farber Cancer Institute, Inc. (DFCI) to research the association between clonal hematopoiesis (CH) and inflammatory disease outcomes. The goal is to define the relationship between CH and rheumatologic diseases, identify CH genotypes linked to inflammatory phenotypes, and explore the influence of hypomethylating agent therapy on...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $1,085,789 to the Albert Einstein College of Medicine to investigate the prevalence, mutational spectrum, and evolution of clonal hematopoiesis (CH) in populations with exceptional longevity. The research aims to: 1) Determine the relationship between CH and age-related diseases in centenarians and their offspring compared to controls; 2) Analyze longitudinal changes in CH incidence and clonal profiles over a 5-year period; and 3) Identify biological pathways that modify the risk of CH and associated diseases. The study will leverage well-characterized Ashkenazi Jewish longevity cohorts to provide novel insights into the complex interplay between CH, aging, and age-related health outcomes. The findings may elucidate protective mechanisms against harmful CH variants, contributing to a better understanding of human lifespan and healthspan.

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