This Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) provides $835,825 to the University of Massachusetts Medical School to conduct research on somatic mutations in Alzheimer's disease. The project aims to analyze patterns of somatic single nucleotide variants, short insertions/deletions, and structural variants in neurons from Alzheimer's disease brains across disease progression. It will also examine how these...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
The University of Massachusetts Medical School (UMass Medical) was awarded a $1,507,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to conduct a study on spatial single-cell analysis of somatic mutations in the human brain during aging and neurodegeneration. The goal is to develop and apply new single-cell whole-genome sequencing methods to study somatic mutations in neurons from late-stage Alzheimer's disease and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $913,225.00 in funding to St. Jude Children's Research Hospital Inc. to conduct research on Alzheimer's disease (AD) and AD-related dementias (ADRD). The project aims to systematically characterize the aggregation of U1 small nuclear ribonucleoprotein (U1 SNRNP) and its role in RNA splicing dysfunction, a key event in AD pathogenesis. The research will utilize human brain specimens, mouse...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $515,160.00 to The Johns Hopkins University to study the relationship between cell-free DNA (cf-DNA) and microglial activation in Alzheimer's disease (AD). The research aims to: 1) examine associations between serum cf-DNA levels and microglial activation, and 2) investigate functional changes in microglial phagocytosis and pro-inflammatory pathway activation when exposed to purified cf-DNA from...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $2,488,671.00 from September 1, 2024 through June 30, 2029 to Washington University in St. Louis to conduct research on the impact of inherited and modifiable risk factors on clonal hematopoiesis (CH) and its association with age-related diseases like cardiovascular disease and Alzheimer's disease. The study will leverage longitudinal data from large biobanks and cohorts to characterize...
This $614,424 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand the role of microglia, the brain's immune cells, in the development of Alzheimer's disease (AD). The University of Washington (UW) will leverage novel explainable AI techniques and human induced pluripotent stem cell (iPSC) models to uncover subtle microglial changes that occur early in AD progression. Specifically, UW will expose microglia-neuron iPSC cultures to...
This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...