This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $414,521 to The Regents of the University of California, doing business as the University of California, Berkeley, for a 2-year research project. The goal is to develop cultured elephant seal cells as a model system to identify new mechanisms that suppress oxidative stress and ferroptosis, a form of regulated cell death. The project aims to use CRISPR-Cas9 genetic editing tools and genome-wide screens to uncover pathways that provide elephant seal cells with resistance to oxidative damage and ferroptosis. This work has the potential to yield insights into the etiology of degenerative diseases associated with oxidative stress and identify new therapeutic strategies. The award period runs from September 30, 2023 to September 29, 2025.
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