Project Grant R01AG087959

Award Date 8/15/24
Completion Date 7/31/29
Dollars Obligated $867K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $126,956 to the University of California, San Diego (UCSD) to conduct research on generating new neurons in the aging adult brain. The key objectives are to: Use single cell spatial transcriptomics to define the cellular pathway and molecular mechanisms underlying the conversion of glial cells into functional replacement neurons in the aged mouse brain. This approach was previously...
This federal Project Grant award, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research into the role of senescent cells in brain aging and Alzheimer's disease and related dementias (ADRD). The $654,238 award, with a start date of September 15, 2024 and an ultimate completion date of June 30, 2026, aims to generate high-resolution spatial omics data from ADRD brains and corresponding mouse models to identify molecular changes in the...
This federal Project Grant award, valued at $131,027.00, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to The Leland Stanford Junior University. The award aims to study neuronal proteostasis, the maintenance of protein health, during brain aging and Alzheimer's disease (AD). The key products and services to be delivered under this grant include: Conducting in vivo experiments using a novel bioorthogonal non-canonical amino acid tagging (BONCAT)...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $173,140 to The Regents of the University of California, San Francisco (UCSF) to investigate the role of neural activity in the degeneration of midbrain dopamine neurons associated with Parkinson's disease. The project aims to develop novel mouse models to chronically...
This $3,845,311 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research at the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using patient-derived induced neurons (iNs). The project aims to better understand the mechanisms that cause mild cognitive impairment (MCI) and the progression to AD, integrating multi-omic analysis of MCI patient-specific iNs with polygenic risk scores....
This federal Project Grant award in the amount of $684,451 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders supports a comprehensive research effort to advance understanding and treatment of Parkinson's disease. The project aims to: Identify Parkinson's disease progression subtypes through integrative analysis of longitudinal clinical, transcriptomic, and neuroimaging data...
This Project Grant award of $1,086,563.00 from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research conducted by The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, to define the regulation of lysosome-mediated pathways within and between astrocytes and neurons in response to proteotoxic stress from alpha-synuclein aggregation. The research aims to elucidate cell-type-specific...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $414,521 to The Regents of the University of California, doing business as the University of California, Berkeley, for a 2-year research project. The goal is to develop cultured elephant seal cells as a model system to identify new mechanisms that suppress oxidative stress and ferroptosis, a form of regulated cell death. The project aims to use CRISPR-Cas9 genetic editing tools and...
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The project aims to leverage stem cell-derived organoids, primary tissue samples, machine learning, and CRISPR techniques to directly measure dynamic gene regulatory responses and candidate neuroprotective pathways in human versus non-human primate dopaminergic neurons under oxidative stress. This research seeks to determine the genomic elements and genetic changes underlying stress-dependent responses in these vulnerable cell types, which could lay the groundwork for targeting cellular protective mechanisms across age-related disorders.

The award includes a $197,156 sub-grant to the J. David Gladstone Institutes to develop computational strategies for decoding the sequence grammar of stress-responsive regulatory elements and predicting the impact of human-specific variants on enhancer function.

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