Elucidating the role of neural activity in midbrain dopamine neuron degeneration
Active Project Grant Awarded Last action
- Award ID
- F31NS137765
- Recipient
-
The Regents Of The University Of California. San Francisco UEI KMH5K9V7S518
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $217,744
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date 75% complete
- Place of performance
- San Francisco, CA 94158, USA
Award details come from USAspending.gov.
Description
- Abstract
- Parkinson's disease (PD) is a debilitating neurodegenerative disease characterized by the progressive loss of substantia nigra pars compacta (SNC) dopamine neurons. The reasons for their selective vulnerability and the mechanisms that drive their degeneration remain unclear. There is mounting evidence that the activity of energetically-burdened SNC neurons is altered in PD, however the role of neural activity in the susceptibility of dopamine neurons is poorly understood. Additionally, while dopamine is known to be toxic to neurons that do not have a means of sequestering or metabolizing IT, the role of dopamine itself in the degeneration of dopamine neurons in PD is not known. To investigate the role of activity in dopamine neuron selective vulnerability, we have developed novel mouse models in which we can chronically manipulate midbrain dopamine neuron activity using chemogenetics. With these models, we propose to determine how chronically manipulating activity and dopamine metabolism within dopamine neurons impacts their susceptibility to degeneration. These experiments will be the first to directly interrogate the role of neural activity in degeneration in a chronic, minimally-invasive manner. Furthermore, they will provide insight for future therapeutic strategies to protect dopamine neurons from degeneration in PD.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $44,604 | |
| Amendment | $44,028 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $1,280 | |
| Amendment | $1,280 | |
| Amendment | $42,184 | |
| Amendment | $42,184 | |
| Original award | $42,184 |
Quick answers
Who received award F31NS137765?
F31NS137765 was awarded to The Regents Of The University Of California. San Francisco by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on September 30, 2024.
How much is award F31NS137765 worth?
$217,744 has been obligated on F31NS137765.
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