Project Grant R01AG086495

Award Date 9/30/24
Completion Date 7/31/29
Dollars Obligated $781K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Stanford, CA 94305, USA
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This federal Project Grant award, valued at $131,027.00, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to The Leland Stanford Junior University. The award aims to study neuronal proteostasis, the maintenance of protein health, during brain aging and Alzheimer's disease (AD). The key products and services to be delivered under this grant include: Conducting in vivo experiments using a novel bioorthogonal non-canonical amino acid tagging (BONCAT)...
This $619,681 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University (Stanford University) aims to develop innovative tools and conduct multi-omics research to better understand the genetic interactions underlying Alzheimer's disease (AD) pathogenesis. The key products to be delivered include: Combo-Seq/Tag, a toolkit combining precise installation of AD risk gene variants (Combo-Seq) with a multiplex protein tagging...
The National Institute on Aging (NIA) awarded a $762,636 Project Grant (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University (Stanford University) to develop interpretable machine learning methods for analyzing the genetics of Alzheimer's disease (AD). The goal is to discover causal genetic variants that could lead to new AD therapies. The project will apply the methods to genetic data from approximately 500,000 samples, with findings validated through functional experiments,...
This Project Grant award of $444,890 from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) will support research by the Regents of the University of California, San Francisco to explore the mechanisms underlying the selective transmission of distinct protein conformers in Alzheimer's disease (AD) and Lewy body dementia (LBD). The research aims to identify key genes that mediate the regional vulnerability to different pathological conformations of the...
This $763,922 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at Stanford University aimed at investigating the shared mechanisms of tau toxicity across neurodegenerative diseases. The key objectives are to understand the normal physiological functions of tau protein, as well as its pathogenic role in conditions like Alzheimer's, Parkinson's, and Huntington's diseases, and how tau interacts with mitochondrial dysfunction. The research...
This $2,307,075 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports an ambitious research program at The Leland Stanford Junior University. The funded research aims to define novel mechanisms underlying human neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Parkinson's disease, and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $227,250 to Saint Louis University to investigate the role of the protease cathepsin L in modulating the nuclear proteome, particularly in relation to lamin proteins involved in cellular aging and disease. The 2-year project, running from November 2024 to October 2026, aims to elucidate the mechanisms by which cathepsin L can mitigate the toxic effects of the progerin protein that causes...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,912,818.00 to investigate the mechanisms by which clonal hematopoiesis of indeterminate potential (CHIP) is associated with reduced risk of Alzheimer's disease (AD). The primary awardee, The Leland Stanford Junior University, will conduct research to: 1) identify how specific CHIP driver gene mutations and germline variation interact to impact AD risk in large human cohorts, 2) assess changes...
This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
This $913,225 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to systematically characterize protein aggregation and splicing dysfunction in Alzheimer's disease (AD) and related dementias (ADRD). Key objectives include: Utilizing human brain specimens, mouse models, and human iPSC-based neuron and brain organoid models to study U1 small nuclear ribonucleoprotein (U1 SNRNP) proteinopathy and its interactions with other AD/ADRD...

This $780,644 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) aims to investigate the relationship between protein phase separation, aggregation, and the age-dependency of human diseases. The research will leverage comprehensive libraries of disease-associated protein mutations to define how phase separation and aggregation processes contribute to the onset and progression of age-related diseases. Key objectives include:

  1. Defining the phase separation properties of proteins involved in diverse human diseases.
  2. Characterizing the aggregation and "prion-like" seeding behaviors of disease-associated protein variants.
  3. Identifying both protein-autonomous and age-related systemic factors that drive altered phase separation in the context of disease.

The 5-year project will be conducted by the Leland Stanford Junior University (Stanford University) to advance the understanding of how protein biophysics and age-related changes impact the development of age-dependent disease pathologies. The research is expected to provide insights for potentially mitigating the impact of dominant disease alleles as individuals age.

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