This $125,896 Project Grant, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports a research project led by The Washington University in St. Louis. The project aims to utilize state-of-the-art single-nuclei multi-omic functional genomic analyses of healthy and Alzheimer's disease (AD) human brain tissue, as well as transgenic AD mouse models, to perform deep molecular characterization of AD risk and resilience pathways across genetic, epigenomic,...
This $459,076 federal Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the early transcriptional and pathological changes in vulnerable brain regions during the prodromal stage of Alzheimer's disease (AD). The project will leverage single-nucleus RNA sequencing and targeted mass spectrometry analysis of postmortem brain samples from individuals with early-stage AD pathology to profile gene expression changes and identify...
This federal Project Grant award of $528,876.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University will support a 5-year research study to investigate the genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias (AD/ADRD). The key objectives are to: Estimate genome-wide cis- and trans-acting quantitative trait loci (QTLs) for transcriptome-wide genes and proteome-wide proteins across multiple brain...
This $328,000 federal Project Grant award is funded by the National Institute on Aging under the Aging Research program (CFDA 93.866). The grant supports the Alzheimer's Disease Organelle Proteome Task (ADOPT) pilot phase, which aims to quantitatively measure the organelle proteome to provide in-depth knowledge of organelle homeostasis and function in brain tissues during Alzheimer's disease progression. The interdisciplinary research team will utilize a genetic organelle tagging approach to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $784,596 to Northeastern University to conduct comprehensive and cell type-specific proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The 5-year project aims to improve understanding of AD's causes, identify new therapeutic targets, and develop new tools for studying protein dysfunctions in AD. Key objectives include applying...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a study to characterize spatial variations in RNA isoform expression associated with Alzheimer's disease (AD). The $423,994 award to Duke University will leverage single-nucleus cDNA, long-read RNA sequencing, and in situ sequencing to profile isoform expression at single-cell resolution in the inferior frontal gyrus region, which is pertinent to AD. The study aims to identify cell-type...
This federal Project Grant award for $310,000 from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at Texas Tech University Health Sciences Center (TTUHSC) to examine the role of alternative polyadenylation (APA) of mRNAs in the development and progression of Alzheimer's disease (AD). The key goals are to: 1) Identify APA genes and pathways associated with AD pathology using computational analysis of existing single-cell RNA sequencing datasets, and 2)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $794,341 will support research to investigate the mechanistic roles of cellular senescence and blood-brain barrier dysfunction in mediating pathogen-induced progression of Alzheimer's disease. The research will leverage experimental mouse models, molecular characterization of endogenous retrovirus RNA sensing, and human induced pluripotent stem cell (iPSC) models. Key objectives...
This $466,125 Project Grant award, funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research to investigate the effects of Alzheimer's disease (AD) on subcellular transcriptome dynamics and mitochondrial-nuclear (mitonuclear) coordination in neurons. The primary awardee, President and Fellows of Harvard College (doing business as Harvard Medical School), will adapt a novel RNA-flow analysis technique (STL-SEQ) to quantify transcription, nuclear...
This federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), provides $6,226,692 to The Trustees of Columbia University in the City of New York to conduct research on the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the progression of Alzheimer's disease. The research aims to identify key early events in Alzheimer's disease pathology, particularly in the locus coeruleus and hippocampus regions of the brain, and...