The National Institute on Aging (NIA) awarded a $619,681 Project Grant (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University (Stanford University) to develop innovative tools for studying the complex genetic interactions underlying Alzheimer's disease (AD) pathogenesis. The project, titled "Combinatorial Perturbation with Multi-Omics Readout to Dissect Etiology of Alzheimer's Disease Using Stem Cell and In Vivo Models", will create a toolkit combining gene-editing...
The National Institute on Aging (NIA) awarded a $350,001 Project Grant (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) to unravel the role of clonal hematopoiesis (CH) in neurodegenerative diseases. The project will leverage genomic and functional data to investigate the associations between different CH types, including clonal hematopoiesis of indeterminate potential (CHIP), autosomal mosaic chromosomal alteration (MCA), and loss of the Y chromosome...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $2,488,671.00 from September 1, 2024 through June 30, 2029 to Washington University in St. Louis to conduct research on the impact of inherited and modifiable risk factors on clonal hematopoiesis (CH) and its association with age-related diseases like cardiovascular disease and Alzheimer's disease. The study will leverage longitudinal data from large biobanks and cohorts to characterize...
This Project Grant award of $2,683,965 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support the development and optimization of an improved all-human cellular system, or "brain-chip", for studying Alzheimer's disease and related dementias (ADRDs). The key objectives are to: 1) define delivery conditions for introducing patient blood cells and plasma into...
This Project Grant award of $2,653,601 from the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) supports research to identify genetic, environmental, and molecular factors that influence the rate of clonal hematopoiesis (CH) expansion and associated health outcomes across the human lifespan. The key objectives are to: 1) apply a computational method to estimate CH expansion rates in over 1.6 million individuals to identify genetic factors conferring...
This Project Grant award of $762,636 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports the development of interpretable machine learning methods for analyzing Alzheimer's disease genetics. The research aims to improve understanding of the complex genetic basis of Alzheimer's disease and identify novel therapeutic targets. Key objectives include applying advanced machine learning techniques to large-scale genetic and multi-omics datasets, while...
The National Institutes of Health's National Institute on Aging awarded a $7,432,562 project grant to the Regents of the University of California, San Francisco on September 15, 2022 under the Aging Research program (CFDA 93.866). The grant will support research to elucidate the roles of Alzheimer's disease risk genes and variants in gene expression and AD-related phenotypes through 2025. Specifically, the University of California, San Francisco will use CRISPR and single-cell RNA sequencing...
This federal Project Grant award, valued at $131,027.00, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to The Leland Stanford Junior University. The award aims to study neuronal proteostasis, the maintenance of protein health, during brain aging and Alzheimer's disease (AD). The key products and services to be delivered under this grant include: Conducting in vivo experiments using a novel bioorthogonal non-canonical amino acid tagging (BONCAT)...
This $614,424 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand the role of microglia, the brain's immune cells, in the development of Alzheimer's disease (AD). The University of Washington (UW) will leverage novel explainable AI techniques and human induced pluripotent stem cell (iPSC) models to uncover subtle microglial changes that occur early in AD progression. Specifically, UW will expose microglia-neuron iPSC cultures to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $654,238 to The University of Texas Health Science Center at San Antonio to study the role of senescent cells in Alzheimer's disease and related dementias (ADRD). The primary goals are to: Identify molecular markers and changes in the microenvironment of senescent neurons compared to healthy neurons, with a focus on their contribution to neuronal death in brain aging and ADRD (R21 phase). Use...
This Project Grant award of $4,313,443, provided by the National Institute on Aging under the Aging Research (CFDA 93.866) program, will fund research to uncover the mechanisms by which clonal hematopoiesis of indeterminate potential (CHIP) protects against Alzheimer's disease (AD). The key objectives are to: 1) identify specific CHIP gene mutations and their interactions with germline variation that impact AD risk in large human cohorts, 2) assess changes in mutant microglial fraction and density in CHIP using brain samples, and 3) evaluate alterations in microglial cell state and gene expression associated with CHIP through advanced imaging and single-cell genomics. The research will be conducted by The Leland Stanford Junior University, with sub-awards to Banner Health and the University of Washington to provide critical brain samples, neuropathology expertise, and research consultation. The expected outcome is to delineate the genetic and cellular mechanisms by which CHIP confers protection against AD, with the long-term goal of stimulating the development of novel AD therapies that mimic these protective effects.