Project Grant RF1AG093462
- This $2,991,725 Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research into the role of reactive oxygen species as modulators of lifespan and age-related diseases. The 4-year project, which commenced on September 1, 2025, aims to investigate a novel longevity paradigm in C. elegans that is triggered by early-life oxidative stress and mediated by changes in the epigenetic landscape. The research will examine the conserved mechanisms...
- The National Science Foundation awarded a $138,000 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to support research titled "A Novel Model System for Studying the Evolution and Genomics of Longevity" from July 1, 2021 to June 30, 2023. The two-year award will fund the development of a new model organism to advance understanding of longevity through the study of evolution and genomics. The Biological Sciences program aims to promote progress in the...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $551,986.00 to The Jackson Laboratory to develop an explainable unified AI strategy for efficient and robust integrative analysis of multi-omics data from heterogeneous longevity studies. The goal is to identify protective genetic variants associated with exceptional human longevity, which can inform therapeutic interventions to improve human health. The 2-year project aims to: 1) create...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- This federal Project Grant award of $291,913 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Virscio, Inc., a for-profit research company located in Connecticut. The award is focused on developing epigenetic and senescent biomarkers using non-human primate tissues to advance the understanding of biological aging processes and potential anti-aging strategies. The project aims to create minimally invasive biomarker tools, such as blood and skin-based assays,...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- This federal Project Grant award of $438,625.00 from the National Institute on Aging (CFDA 93.866 Aging Research) to Brown University aims to study how the cellular senescence phenotype changes over time and develop technology to track the duration of cells in senescent states. The key objectives are to (1) examine how the senescence phenotype, including the senescence-associated secretory phenotype (SASP), evolves from early to deeper states, and (2) advance a multi-symbol molecular recorder...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
- This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,359,000.00 to Baylor College of Medicine to conduct research on age-associated cellular and molecular adaptations that enable whole-organism rejuvenation in the highly regenerative flatworm Schmidtea mediterranea. The research aims to (1) determine how age-associated damage manifests in asexual planaria throughout their lifecycle...
- Duke University received a $1,019,484.58 Project Grant award from the National Institutes of Health's National Institute on Aging under the Aging Research program (CFDA 93.866) for the period September 1, 2021 through May 31, 2022. The award will support research using the nematode C. elegans as a model organism to study aging-associated neurodegeneration at the molecular level, with the goals of uncovering novel mechanisms underlying this process and establishing C. elegans neurons as a...
This federal Project Grant award of $1,875,196.00 from the National Institute on Aging (CFDA 93.866 Aging Research) aims to investigate the genetics of exceptional longevity in the ocean quahog, the world's longest-living animal. The research will study genome-wide patterns of selection related to lifespan variation within and across bivalve species, with a focus on the ocean quahog. By leveraging this natural experiment in extreme longevity, the project seeks to identify core physiological mechanisms that can inform approaches to extend lifespan and healthspan. The award was granted to the Children's Hospital Corporation, doing business as Boston Children's Hospital, a leading medical research institution, with a performance period from August 2025 to July 2029. The research aims to provide insights into aging processes that could significantly impact healthcare and quality of life.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.9m | 8/4/25 |