This federal Project Grant award of $752,589.00 from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research aims to study the relationship between pathologies in peripheral nerves and the brain, as well as the impact of brainstem pathology and synapse loss, in individuals who died with Alzheimer's disease or related dementias. The award to the University of Iowa, a major public research university, will fund a 5-year research project starting on January 1, 2025 to address the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $795,436 to Rutgers, The State University of New Jersey to elucidate the role of the glycoproteome in Alzheimer's disease and related disorders (AD/ADRD). The award period is from Apr 1, 2025 to Feb 28, 2030. The study aims to: 1) identify glycopeptiforms related to AD/ADRD pathologies and clinical traits; 2) test if glycopeptiforms link an active lifestyle with brain health; and 3)...
This $6,226,692 project grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research to examine the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the development of Alzheimer's disease (AD). The primary focus is on investigating how modifications in brain activity, particularly in the locus coeruleus (LC) and hippocampus (HPC) regions, can lead to the key pathological hallmarks of AD....
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $622,000 to the University of Maryland, Baltimore to conduct research on the role of mitochondrial complex I deficiency in Alzheimer's disease and dementia. The primary goals are to: 1) Determine the effects of complex I deficiency on humanized amyloid-beta proteinopathy, and 2) Assess the susceptibility of complex I-deficient mice to Alzheimer's disease and dementia. The research will utilize...
This Project Grant award of $372,690 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to discover the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The project will develop new statistical methods to uncover how amyloid-beta, tau accumulation, and cognition are causally related in different AD subpopulations. The goal is to reveal optimal treatment windows and target groups for therapies that reduce amyloid-beta or...
This $338,527 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to understand the role of inhibitory interneurons in the pathophysiology of Alzheimer's disease (AD) and related dementias (ADRD). The key objectives are to: 1) Identify disrupted interneuron gene expression in post-mortem AD brain tissue, 2) Characterize inhibitory dysfunction in AD-derived induced interneurons in vitro, and 3) Assess the impact of transplanting healthy...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $3,038,050 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to study the molecular mechanisms of Alzheimer's disease. The funded research aims to discover a novel oxidative stress pathway that targets microglia, the immune cells in the brain, leading to their dysfunction and detrimental consequences in Alzheimer's disease. The goal is to develop...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $385,612 aims to integrate experimental and computational models to study prefrontal microcircuit changes during healthy aging and Alzheimer's disease progression. The research team at the University of Wyoming will use in vivo calcium imaging, computational simulation modeling, and neural decoding to directly visualize and predict microcircuit changes in the prefrontal cortex. A sub-award of an...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) provides $2,257,275 to the University of Toledo Health Science Campus Division to conduct a multi-omics, hypothesis-generating investigation of active kinome networks associated with the progression of Alzheimer's dementia (AD). The project aims to 1) identify protein kinase networks and nodes linked to AD progression, 2) validate these protein kinase nodes across...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $3,772,856 to The University of Iowa to investigate the role of glycolysis, a key aspect of glucose metabolism, in Alzheimer's disease (AD) progression using rodent models. The research aims to better understand how disruptions in glycolysis contribute to neurodegeneration in AD, and explore whether improving glycolysis can mitigate disease symptoms. The award period runs from Sep 30, 2024 to May 31, 2029. This work could have significant implications for developing novel disease-modifying therapies for AD and related neurodegenerative conditions.