Project Grant R21AG087909
Award Date
9/1/24
Completion Date
6/30/26
Dollars Obligated
$386K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Laramie, WY 82071, USA
Similar Awards
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $636,342 to Trustees of Boston University's Boston University Medical Campus to conduct multiscale modeling and empirical studies of normal and pathological brain aging. The research aims to elucidate the relationships between myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the dorsolateral prefrontal cortex, and how these changes contribute to age- and Alzheimer's...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $678,029 to the University of Maryland, Baltimore to develop a Bayesian computational system for modeling longitudinal functional microcircuits and using it to examine microcircuit changes in a TDP-43 knockout mouse model. The project aims to advance the state-of-the-art in data analysis and modeling for longitudinal calcium imaging, leveraging Bayesian machine learning to address challenges...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $416,480 to the University of Washington to map the landscape of the aged human brain and develop neurodegenerative disease models. The award will fund a two-phase research project that aims to: 1) identify molecular drivers of brain aging by applying explainable artificial intelligence (XAI) methods to human brain datasets, and 2) manipulate these aging drivers in human induced pluripotent stem...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University from November 2024 to January 2026 to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The project will use a multilevel, multimodal framework including behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $459,004 to Yale University to leverage machine learning models and functional genomics to study the impact of aging on Alzheimer's disease. The project aims to: Develop a cell-type specific regulatory network model for normal brain aging and Alzheimer's brain aging, and Generate empirical data to resolve Alzheimer's risk regulatory loci with differential activity in donor-matched young...
This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,929,011 to The Regents of the University of California, San Francisco (UCSF) to conduct a longitudinal, multimodal neuroimaging study investigating the role of neuronal dysfunction and hyperexcitability in the early biological progression of Alzheimer's disease. The study aims to elucidate the earliest manifestations of neural circuit hyperexcitability that predict the accumulation of tau...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $466,125 to New York University (NYU) to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The project aims to generate brain charts of quantitative dMRI and mesoscopic MRI (mesoMRI) markers across the lifespan, creating a brain microstructure age framework. This framework will then be used to evaluate the effects of...
This $6,226,692 project grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research to examine the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the development of Alzheimer's disease (AD). The primary focus is on investigating how modifications in brain activity, particularly in the locus coeruleus (LC) and hippocampus (HPC) regions, can lead to the key pathological hallmarks of AD....
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $128,321.00 to the Regents of the University of Michigan to systematically dissect the retrosplenial cortex (RSG) circuitry in preclinical Alzheimer's disease (AD) mouse models. The key objectives are to: Study biophysical changes in different RSG cell types in two AD mouse models and two age points, in both male and female mice, to generate a cell-type specific physiological map of RSG...