Project Grant R01AG084660

Award Date 9/1/24
Completion Date 4/30/29
Dollars Obligated $1.6M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Raleigh, NC 27695, USA
Similar Awards
This National Institute on Aging (NIA) Project Grant award, under the Aging Research Federal Grant Program (CFDA 93.866), will fund a 5-year, $3,127,512 study titled "MAEVE: MICROBIOTA MEDIATED FLAVONOID METABOLITES FOR COGNITIVE HEALTH". The study will be conducted by researchers at the University of California, Los Angeles (UCLA) and aims to investigate the protective effects of polyphenol-rich dietary supplements on brain health and cognitive function in older adults at high risk of...
The National Institute on Aging (NIA) awarded a $2,451,933 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to Brigham & Women's Hospital Inc. for the project "The Microbiome-Gut-Brain Axis and Personalized Mediterranean Diet Interventions for Alzheimer's Dementia Prevention". The project aims to investigate how the gut microbiome and Mediterranean diet interventions impact cognitive health and Alzheimer's disease risk. Key research activities include:...
The federal Project Grant award, identified as R56AG086504, was provided by the National Institute on Aging under CFDA Program 93.866 (Aging Research). The $647,979 award supports research at the University of Massachusetts Medical School to investigate how gut microbiota influence neuronal function and protect against neurodegeneration, with a focus on understanding the molecular mechanisms underlying the relationship between the microbiome and Alzheimer's disease. Specifically, the project...
The University of Chicago received a $486,611 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) with a project period from September 30, 2023 to September 29, 2025. The purpose of this grant is to conduct a study examining the effect of cocoa flavanols on the gut microbiome and functional performance in individuals with peripheral artery disease (PAD). The study aims to: 1) determine if baseline gut microbial diversity and composition are...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $849,904 to the University of South Florida to conduct research on the role of microRNAs (miRNAs) in the gut-brain axis and their potential to predict risk of cognitive decline in older adults. The project will determine unique miRNA signatures that originate from the gut and appear in the blood of older adults with mild cognitive impairment (MCI) and dementia, compared to cognitively healthy...
This $369,886 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a research project led by the University of Wisconsin-Madison to investigate the relationship between the gut microbiome and brain health in Alzheimer's disease and other dementias. The key components of the project include: Designing specialized transformer-based machine learning models to analyze associations between gut microbiome composition and brain health metrics, including...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,358,537 to the University of Pittsburgh for a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults." The project aims to elucidate the impact of epigenetic aging and social determinants of health on cognitive function, brain health, and response to exercise interventions in non-cognitively impaired older adults. The research will...
The University of South Florida received a $3,385,215 Project Grant award from the National Institute on Aging, part of the National Institutes of Health within the Department of Health and Human Services. The grant was awarded under the Aging Research program (CFDA 93.866) to fund research titled "Microbial Therapy Improves Gut Permeability to Reduce Cognitive Decline and Alzheimer's Disease." The grant will support research from August 2021 through July 2024 to study the impact of...
The National Institute on Aging (NIA) has awarded a $1,545,208 Project Grant (Federal Grant Program 93.866 - Aging Research) to the Florida Institute for Human & Machine Cognition Inc. (IHMC) to conduct a 5-year study on "Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults." The key objectives of this study are to: 1) Interrogate the role of aging hallmarks such as proteostasis, mitochondrial function, inflammation, and...
This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how...

The National Institute on Aging (NIA) has awarded a $1,639,075 Project Grant (CFDA 93.866 - Aging Research) to North Carolina State University (NC State) to investigate the effects of combined flavonoid-rich diet and physical exercise on age-related cognitive changes, mediated by the gut microbiome.

The study will examine the cognitive impacts of a 12-week blueberry intake regimen, both with and without regular moderate exercise, in an older adult population experiencing age-related cognitive declines. It will also investigate the associations between observed cognitive changes and microbiome alterations using shotgun metagenomics. Additionally, a mouse model will be used to isolate the mechanistic role of the gut microbiome in linking diet, exercise, and cognitive outcomes in aging. This multifaceted project aims to determine how dietary flavonoids and physical activity can influence cognitive change in the aging population through gut microbiome modulation. The award period runs from September 1, 2024 to April 30, 2029.

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