The University of Chicago has been awarded a $984,000 Cooperative Agreement from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding will support a cross-sectional and longitudinal study of gut microbiota in Parkinson's disease patients. The goal is to gain a better understanding of the role of gut dysbiosis in the development, progression, and prognosis of...
This is a Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant, titled "MAEVE: MICROBIOTA MEDIATED FLAVONOID METABOLITES FOR COGNITIVE HEALTH", will provide $3,127,512 in funding over a 5-year period from July 2024 to June 2029 to the University of California, Los Angeles (UCLA) to conduct a randomized, double-blind, placebo-controlled study on the effects of dietary polyphenol supplementation on cognitive function,...
This National Institute on Aging (NIA) Project Grant (CFDA 93.866 - Aging Research) provides $1,639,075.00 in funding to North Carolina State University to study the effects of combined flavonoid-rich diet and physical activity on cognitive function in older adults, mediated by the gut microbiome. The project has three main aims: 1) Examine the cognitive effects of a 12-week blueberry intake regimen with and without regular moderate exercise in older adults experiencing age-related cognitive...
This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how...
This $825,135 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the Massachusetts General Hospital to investigate the relationships between gut microbiome-related metabolites, cerebrovascular disease, Alzheimer's disease biomarkers, and cognitive impairment. The research will leverage data from the REGARDS and CARDIA longitudinal cohort studies to examine associations between gut microbiome metabolites, brain imaging markers, and the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Massachusetts Medical School is focused on understanding how the gut microbiome influences neurodegeneration and protects against Alzheimer's disease. The $647,979 award, effective September 30, 2024 through August 31, 2025, will leverage the C. elegans model system to: Determine how bacterial production of vitamin B12 protects against neurodegeneration pathways. Examine...
This $1,102,206 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a research project at the University of Wisconsin-Madison to characterize the relationship between the gut microbiome and the aging brain, with a focus on understanding the role of the gut microbiome in the development of debilitating neurodegenerative diseases such as Alzheimer's disease. The key components of the project include: 1) Developing specialized...
This $630,905 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) will fund research to characterize the relationship between the gut microbiome-derived metabolite imidazole propionate (IMP), disruption of the blood-brain barrier, and Alzheimer's disease (AD) pathology. The central hypothesis is that IMP modulates AD and related dementias by altering vascular endothelial function and blood-brain barrier permeability. The research will...
This Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,015,766 in funding to the University of Texas Health Science Center at Houston to study the impact of circadian-microbiome interactions on the gut-pancreas axis in aging. The project aims to investigate how disruptions to circadian rhythms affect the intestinal barrier, gut microbiome, and pancreatic health, with the goal of identifying novel anti-aging mechanisms that could be...
The University of Alabama at Birmingham (UAB) has been awarded a $1,869,019 Project Grant by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding will support a 3-year research project to investigate the role of circadian rhythms, gut microbiome, and gut-to-brain signaling in the onset and progression of Alzheimer's disease (AD) using a Drosophila (fruit fly) model. Key objectives include determining whether depletion of gut microbiota...