This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award provides $270,000 in funding from March 1, 2026 to February 28, 2029 to support a postdoctoral research fellowship focused on elucidating the chemical potential of the small intestinal microbiome. The research aims to enhance the mechanistic understanding of the interplay between the small intestine, distal gastrointestinal tract, and host by: Characterizing the composition and metabolic capabilities...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Massachusetts Medical School is focused on understanding how the gut microbiome influences neurodegeneration and protects against Alzheimer's disease. The $647,979 award, effective September 30, 2024 through August 31, 2025, will leverage the C. elegans model system to: Determine how bacterial production of vitamin B12 protects against neurodegeneration pathways. Examine...
The National Science Foundation awarded a $996,521 project grant under the Biological Sciences program (CFDA 47.074) to the Carnegie Institution of Washington for the period of April 1, 2021 through March 31, 2024. The goal of the research project is to scale single-cell physiology studies to better understand community stability in the natural gut microbiome. As part of this work, Johns Hopkins University will expand its microbiome curriculum to additional middle schools in Baltimore County...
This NSF Biological Sciences (CFDA 47.074) Project Grant award of $600,000 to Emory University will investigate how microbiome communities, which are communities of bacteria and other microbes that live in and on organisms, can resist change and transition to alternate states. The project will use the nematode worm Caenorhabditis elegans as a model host to better define the stability and properties of alternate microbiome states, as well as how factors like antibiotic treatment and host...
The University of South Florida received a $3,385,215 Project Grant award from the National Institute on Aging, part of the National Institutes of Health within the Department of Health and Human Services. The grant was awarded under the Aging Research program (CFDA 93.866) to fund research titled "Microbial Therapy Improves Gut Permeability to Reduce Cognitive Decline and Alzheimer's Disease." The grant will support research from August 2021 through July 2024 to study the impact of...
The National Science Foundation awarded a $207,000 Project Grant to support research titled "Diet and the Microbiome as Drivers of Host Tolerance and Resistance to Parasites" from February 1, 2021 through January 31, 2024. The grant was awarded under the Biological Sciences program (CFDA 47.074) to conduct basic research promoting advancement in the biological sciences. Funding will support the grantee's investigation into how diet and the gut microbiome influence an organism's...
The National Science Foundation awarded a two-year, $138,000 Project Grant to support research titled "Extremes in the Interplay: The Development and Effects of Gut Microorganisms within Earth's Largest Terrestrial Species." The grant was awarded on August 1, 2021 under the Biological Sciences program (CFDA 47.074) to be conducted in Fort Collins, Colorado through July 31, 2023. The $138k grant will fund research examining the gut microbiomes of large terrestrial species and how...
This $825,135 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the Massachusetts General Hospital to investigate the relationships between gut microbiome-related metabolites, cerebrovascular disease, Alzheimer's disease biomarkers, and cognitive impairment. The research will leverage data from the REGARDS and CARDIA longitudinal cohort studies to examine associations between gut microbiome metabolites, brain imaging markers, and the...
The National Institute on Aging (NIA) awarded a $558,222 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Maryland, Baltimore to investigate the roles of the CircHIPK3 circular RNA and the HuR RNA-binding protein in regulating intestinal barrier function during aging. The 5-year research project (Sep 2024 - Aug 2029) aims to elucidate how CircHIPK3 and HuR modulate mitochondrial function in the aging intestinal epithelium, and how these molecular...
This Project Grant award of $387,006 from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to understand how indoles derived from commensal gut bacteria can promote mobility and counteract sarcopenia (age-related muscle wasting) in aging animals. The research aims to determine the mechanisms by which indoles regulate muscle protein homeostasis, mitochondrial function, and other cellular pathways to maintain muscle mass and function during...
This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how these changes may impact aging in the brain and muscle, and whether strengthening the intestinal barrier can reverse or delay aging phenotypes. This research will be conducted by a diverse group of undergraduate students, providing them with research experiences to potentially pursue biological research careers. The project will run from August 15, 2023 to July 31, 2026.