The National Institute on Aging (NIA) awarded a $2,451,933 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to Brigham & Women's Hospital Inc. for the project "The Microbiome-Gut-Brain Axis and Personalized Mediterranean Diet Interventions for Alzheimer's Dementia Prevention". The project aims to investigate how the gut microbiome and Mediterranean diet interventions impact cognitive health and Alzheimer's disease risk. Key research activities include:...
The National Institute on Aging (NIA) has awarded a $1,639,075 Project Grant (CFDA 93.866 - Aging Research) to North Carolina State University (NC State) to investigate the effects of combined flavonoid-rich diet and physical exercise on age-related cognitive changes, mediated by the gut microbiome. The study will examine the cognitive impacts of a 12-week blueberry intake regimen, both with and without regular moderate exercise, in an older adult population experiencing age-related cognitive...
The federal Project Grant award, identified as R56AG086504, was provided by the National Institute on Aging under CFDA Program 93.866 (Aging Research). The $647,979 award supports research at the University of Massachusetts Medical School to investigate how gut microbiota influence neuronal function and protect against neurodegeneration, with a focus on understanding the molecular mechanisms underlying the relationship between the microbiome and Alzheimer's disease. Specifically, the project...
This $369,886 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a research project led by the University of Wisconsin-Madison to investigate the relationship between the gut microbiome and brain health in Alzheimer's disease and other dementias. The key components of the project include: Designing specialized transformer-based machine learning models to analyze associations between gut microbiome composition and brain health metrics, including...
This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to study the relationships between gut microbiome-related metabolites, cerebrovascular disease, Alzheimer's disease biomarkers, and cognitive impairment. With a total funding amount of $825,135 awarded on Sep 15, 2024, the project will be conducted by the Massachusetts General Hospital and involving collaborators from the University of Alabama at Birmingham and the University of...
This federal Project Grant award of $787,390.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a comprehensive study to examine the relationship between diet, neuroinflammation, brain oxidative stress, and plasma neurodegenerative biomarkers in a diverse population. The goal is to elucidate the link between diet and Alzheimer's disease (AD) and related dementias (ADRD). The study will leverage data from four longitudinal community cohorts to investigate the...
The National Institute on Aging awarded a $696,896 Project Grant (CFDA 93.866 - Aging Research) to the University of Texas Health Science Center at Houston. The grant will fund research to study the impact of the gut microbiome on B cell-mediated neuroinflammation in cerebral amyloid angiopathy (CAA), an age-related small vessel disease that contributes to intracerebral hemorrhages, stroke, and cognitive decline in the elderly. The 5-year project aims to: 1) Determine if CAA induces B...
The University of South Florida received a $3,385,215 Project Grant award from the National Institute on Aging, part of the National Institutes of Health within the Department of Health and Human Services. The grant was awarded under the Aging Research program (CFDA 93.866) to fund research titled "Microbial Therapy Improves Gut Permeability to Reduce Cognitive Decline and Alzheimer's Disease." The grant will support research from August 2021 through July 2024 to study the impact of...
The University of Alabama at Birmingham (UAB) has been awarded a $1,869,019 Project Grant by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding will support a 3-year research project to investigate the role of circadian rhythms, gut microbiome, and gut-to-brain signaling in the onset and progression of Alzheimer's disease (AD) using a Drosophila (fruit fly) model. Key objectives include determining whether depletion of gut microbiota...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $849,904 to the University of South Florida to conduct research on the role of microRNAs (miRNAs) in the gut-brain axis and their potential to predict risk of cognitive decline in older adults. The project will determine unique miRNA signatures that originate from the gut and appear in the blood of older adults with mild cognitive impairment (MCI) and dementia, compared to cognitively healthy...
This National Institute on Aging (NIA) Project Grant award, under the Aging Research Federal Grant Program (CFDA 93.866), will fund a 5-year, $3,127,512 study titled "MAEVE: MICROBIOTA MEDIATED FLAVONOID METABOLITES FOR COGNITIVE HEALTH". The study will be conducted by researchers at the University of California, Los Angeles (UCLA) and aims to investigate the protective effects of polyphenol-rich dietary supplements on brain health and cognitive function in older adults at high risk of Alzheimer's disease. Key objectives include identifying the impact of polyphenol intake on the gut microbiome, inflammatory markers, and Alzheimer's biomarkers, as well as exploring the causal relationships between polyphenol-induced changes in the gut microbiome and cognitive outcomes. The project will also utilize a reverse translational approach to study the effects of polyphenol-mediated alterations in the human gut microbiome on brain and behavior in a mouse model. The findings from this comprehensive, multi-disciplinary study are expected to inform the development of dietary interventions to prevent or delay the onset of cognitive decline and Alzheimer's disease in at-risk elderly populations.