The National Institutes of Health's National Institute of Child Health and Human Development (NICHD) awarded a $580,637 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Albert Einstein College of Medicine in Bronx, New York. The grant, titled "Sperm Chromatin Structure and Remodeling During Spermiogenesis and Fertilization," supports research to understand the relationship between the establishment of chromatin structure in male gametes (sperm...
This Project Grant award for $658,633 was provided by the National Institute of Child Health and Human Development (NICHD) under the federal Child Health and Human Development Extramural Research program (CFDA 93.865) to study the role of the MEIG1 protein complex in sperm development and chromatin remodeling for normal embryogenesis.
The key products and services to be delivered include:
Dissecting the motor-based protein complex in the manchette structure of developing sperm and studying...
This Project Grant from the National Institutes of Health's National Institute of Child Health and Human Development, titled "Child Health and Human Development Extramural Research," provides $915,000 to the University of Massachusetts Boston to support research examining spermatogonial stem cell regulation and maintenance of male fertility. Specifically, the award will fund two research aims over three years (May 2022 to April 2025) to investigate mechanisms governing...
This federal Project Grant award of $157,000.00 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research at Michigan State University to investigate how the ASZ1 protein recruits PIWI proteins to the intermitochondrial cement (IMC) structures in germ cells for the biogenesis of PIWI-interacting RNAs (piRNAs). This 2-year project aims to reveal the critical protein...
This federal Project Grant award of $441,505 from the National Institute of Child Health and Human Development (NICHD), under the CFDA 93.865 Child Health and Human Development Extramural Research program, supports research to uncover how zinc regulates mammalian sperm function, particularly its role in sperm swimming and fertilization.
The key objectives of this 5-year research project are to: 1) establish the mechanisms by which zinc regulates sperm at mating, 2) delineate the mechanisms of...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $360,125 to the University of Massachusetts Medical School (UMass Medical) to conduct research on the role of maternal transcript UTRs (untranslated regions) in reproductive fecundity.
The research aims to define how the maternal transcript load is established during oogenesis and decoded...
This federal Project Grant award, totaling $255,458.00 and awarded on September 17, 2024, is funded by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports a research project at the Smithsonian Institution to investigate the physiological significance of follicular extracellular vesicle microRNAs and their therapeutic potential for improving assisted reproductive technologies,...
The National Institute of Child Health and Human Development (NICHD) awarded a $148,000 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Southern Mississippi (USM) to conduct a pilot study on the molecular link between cancer and oocyte-based infertility. The key objectives are to:
Investigate the potential molecular mechanisms linking female infertility and cancer, with a focus on the role of the protein phosphatase 1 (PP1) enzyme....
This $133,207 federal Project Grant award was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports a research project to investigate the molecular mechanisms underlying fertilization and egg activation in the Caenorhabditis elegans model organism.
Specifically, the project aims to determine the functions of the PGM-3 and SPE-56 genes in these critical...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $327,875 to Texas A&M AgriLife Research to investigate how the paternal histone epigenome affects early embryo development and pregnancy loss in cattle and humans.
The study aims to: 1) establish the baseline paternal histone epigenome in fertile bulls, 2) determine if the paternal...