This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $1,017,855 to Duke University to study the regulation of fertility and reproduction through codon usage in Drosophila (fruit fly) models. The research aims to identify how tissue-specific differences in mRNA translation, stability, and regulatory proteins impact rare codon expression in the...
The federal Project Grant award R01HD112533, in the amount of $1,407,333.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research at the Albert Einstein College of Medicine to investigate the role of the Rho kinase (ROK) protein and its substrate Combover (CMB) in the male germline of Drosophila, with a focus on understanding their function in...
This $169,500 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research by New York University (NYU) School of Medicine to characterize soma-germline interactions during adult spermatogenesis. The research aims to determine how a secreted, conserved, immunoglobulin (Ig) domain protein maintains the blood-testis barrier in somatic support cells of the...
This Project Grant award, valued at $107,458.00 and issued by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research conducted by Duke University to investigate the mechanisms of double-strand break repair in fetal male germ cells. The central objective is to determine how male germ cells in the G0 quiescent phase respond to and repair double-strand DNA breaks, and to elucidate...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $658,633 to Wayne State University to conduct research on the mechanisms of the MEIG1 protein complex in mammalian spermiogenesis and fertilization. The research aims to explore how the MEIG1 complex plays a role in transporting cargo for sperm tail formation and in remodeling chromatin during...
The National Institute of Child Health and Human Development (NICHD) awarded Yale University a $921,250 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant funds a 2-year project to define the molecular pathways governing chromocenter restructuring before and after fertilization. The study aims to determine how the chromatin regulator DOT1L controls chromocenter disassembly during sperm nuclear condensation, as well as how DOT1L...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research focused on the function and evolution of female-expressed seminal fluid proteins in Drosophila melanogaster. The $124,913 award, effective from September 1, 2024 to August 31, 2026, will enable the University of California, Davis to: 1) investigate the functions of seminal fluid...
The federal Project Grant award R01HD110439, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to uncover how zinc regulates sperm swimming and the mechanisms by which zinc homeostasis changes during the fertilization process. The $1,324,515 award, with a project period from August 16, 2024 to May 31, 2029, will be conducted by the University of Pittsburgh. The...
This Project Grant award of $271,728 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research by the Whitehead Institute for Biomedical Research to uncover the molecular mechanisms that initiate and maintain germ cell identity. The key objectives of the research are to: (a) discover mechanisms that repress somatic programs and allow the primordial germ cell (PGC) program to...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $335,955 to Cornell University to conduct research on how calcium triggers the transition from egg to embryo. The research aims to elucidate the post-translational switches that mediate the conversion of a mature oocyte into a totipotent cell capable of development upon fertilization. Key focus...