Project Grant R01HD114814

Award Date 8/15/24
Completion Date 4/30/28
Dollars Obligated $1.7M
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Bronx, NY 10461, USA
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The key objectives of this research project are to: 1) perform biochemical, biophysical, and structural analyses of in vitro reconstituted Drosophila sperm chromatin, 2) study the factors, such as protamine chaperones and enzymes of the thioredoxin system, that mediate sperm chromatin remodeling, and 3) evaluate small-molecule inhibitors of the thioredoxin system as potential contraceptive agents. This comprehensive research aims to provide insights into the role of chromosome assembly and maintenance in regulating cell function, with applications to understanding, diagnosing, and treating human conditions involving chromatin structure defects.

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