This federal Project Grant award, valued at $1,080,375 and spanning July 2024 to March 2029, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research aimed at defining how the maternal load is established during oogenesis and decoded after fertilization, with a focus on understanding the regulatory mechanisms and environmental factors that impact...
This federal Project Grant award, provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop a novel imaging technology to directly observe and better understand multiple aspects of fertilization within the mouse fallopian tube in vivo. The $674,095 award, with a performance period from December 1, 2024 to November 30, 2029, will enable the integration of expertise in live...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,963,122 to the University of Missouri System to conduct research on the molecular mechanisms regulating uterus development. The research aims to define critical physiological and genetic pathways that govern uterine development, function, and regeneration in order to better diagnose,...
The federal Project Grant award for "The Mechanisms of MEIG1 Complex in Mammalian Spermiogenesis and Fertilization" (Federal Grant Award ID: R01HD114311) is provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $658,633 award, with a project period from August 2024 to April 2029, supports research to investigate the role of the MEIG1 protein complex in sperm formation and...
The National Institute of Child Health and Human Development awarded a $418,194 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Brown University. The grant aims to uncover the developmental and molecular mechanisms underlying the establishment and maintenance of the ovarian follicle reserve in mice, which is relevant to understanding, diagnosing, and potentially treating primary ovarian insufficiency (POI) and infertility in women. Key...
This federal Project Grant award for $271,728 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to uncover the molecular mechanisms that initiate and maintain germ cell identity. The research program will focus on (1) discovering the dynamics of germline gene activation during embryogenesis, (2) identifying germ cell-specific cis-regulatory sequences and transcriptional regulators,...
This $508,315 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training supports research to uncover molecular mechanisms required for successful developmental progression from oocyte to embryo during the window of transcriptional silence in mammals. The overarching goal is to improve understanding of the earliest stages of mammalian development and potential treatments for infertility, as only ~50%...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research program provides $192,056 to the Magee-Womens Research Institute and Foundation to conduct research on adeno-associated virus (AAV) gene therapy to restore fertility in mammalian Sertoli cell dysfunction models. The project aims to demonstrate the feasibility and safety of in vivo Sertoli cell gene therapy using...
The National Institute of Child Health and Human Development (NICHD) awarded a $386,855 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to King's College London to study the role of follicle-stimulating hormone receptor (FSHR) oligomerization and trafficking in mediating age-dependent changes in FSH glycoforms. The research aims to elucidate how the functional differences between the FSH18/21 and FSH24 glycoforms modulate FSHR signaling and behavior within...
This $157,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research at Michigan State University (MSU) on the critical protein interactions involved in the biogenesis of PIWI-interacting RNAs (piRNAs). The project aims to reveal how the mitochondrion-localized protein ASZ1 recruits PIWI proteins to the intermitochondrial cement (IMC) structure...