Project Grant R01HD110439
Award Date
8/16/24
Completion Date
5/31/29
Dollars Obligated
$1.3M
Federal Agency
National Institute of Child Health and Human Development
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research provides $1,713,959 to support research on sperm chromatin structure and remodeling during spermiogenesis and fertilization. The project will conduct biochemical, biophysical, and structural analyses of in vitro reconstituted Drosophila sperm chromatin to understand the relationship between chromatin structure in...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research to investigate the molecular mechanisms underlying fertilization and egg activation in the C. elegans model system. The primary researcher will use a forward genetic screen to identify novel genes involved in sperm-egg binding, fusion, and egg activation. This $133,207 award,...
This Project Grant award, totaling $658,633, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research into the mechanisms of the MEIG1 protein complex in mammalian spermiogenesis and fertilization. The research aims to explore how the MEIG1 complex plays a role in transporting cargo proteins for sperm flagella assembly and in remodeling chromatin during the final...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 Child Health and Human Development Extramural Research, will support a $245,619 research project titled "Investigating the Relationship Between Genome Mutagenesis, Fertility, and Health in Fertile and Infertile Men". The project, awarded to the University of Utah, aims to use advanced DNA sequencing techniques to explore connections between germline and...
The National Institute of Child Health and Human Development (NICHD) awarded a $2,228,898 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Brigham & Women's Hospital Inc. in Boston, MA. The grant will fund the development of a microwell device and deep learning framework to enable efficient identification and retrieval of rare sperm from samples of men with azoospermia (absence of sperm in semen). This technology aims to provide a more...
This Project Grant award, valued at $606,518 and funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to develop and test the safety and feasibility of spermatogonial stem cell (SSC) transplantation and testicular tissue grafting procedures for restoring fertility in patients who previously cryopreserved their testicular tissues. The awardee, Magee-Womens Research...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research - supports research to identify biomarkers of the sperm striated columns, a key component of the sperm centrosome. The $152,834 award to the University of Toledo will be used to examine the composition of the striated columns in bovine spermatozoa and zygotes, with the long-term goal of understanding the contribution...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $107,458 to Duke University to conduct research on mechanisms of double strand break repair in fetal male germ cells. The research aims to determine how male germ cells respond to and repair double-strand DNA breaks during a critical period of quiescence prior to birth, and to elucidate the...
The National Institute of Child Health and Human Development (NICHD) awarded a $413,843 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Pennsylvania State University, doing business as Penn State, to develop advanced biofabricated seminiferous tubules for in vitro spermatogenesis research. The proposed work aims to use micro-extrusion technology to precisely fabricate microtubes that mimic the cellular composition and organization of in vivo...
The federal Project Grant award R01HD118540 was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $401,927 award will fund research to understand the functions of long terminal repeat (LTR) retrotransposon activation in preimplantation development and its regulation of zygotic gene activation (ZGA) and early embryogenesis. The research aims to identify specific...