This Project Grant from the National Institutes of Health's National Institute of Child Health and Human Development, titled "Child Health and Human Development Extramural Research," provides $915,000 to the University of Massachusetts Boston to support research examining spermatogonial stem cell regulation and maintenance of male fertility. Specifically, the award will fund two research aims over three years (May 2022 to April 2025) to investigate mechanisms governing spermatogonial stem cell maintenance in zebrafish. The first aim will study how post-transcriptional RNA regulation by the ADAD1 RNA binding protein impacts spermatogonial stem cell functions like proliferation, differentiation, quiescence, and apoptosis. The second aim will examine how moderate tissue stress from frequent breeding activates spermatogonial stem cells and promotes robust sperm production, including the role of the CDK21 cell cycle regulator. Insights from this research could further understanding of human reproductive health and improve diagnosis and treatment of infertility.
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