This Project Grant award of $221,448 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to determine the role of apoptosis (programmed cell death) in oogenesis (egg cell production) and oocyte (egg cell) health. The research will be conducted at the University of North Carolina at Chapel Hill, under the mentorship of Dr. Amy Shaub Maddox, from June 2025 to March 2028....
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,884,840 to investigate the role of the protein c-Jun N-terminal kinase (JNK) in regulating ovarian damage caused by certain chemotherapy drugs. The research aims to elucidate the molecular mechanisms by which JNK contributes to DNA damage response and apoptotic signaling in primordial...
This Project Grant award, with funding of $658,633 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on investigating the mechanisms of the MEIG1 protein complex in mammalian spermiogenesis and fertilization. The key research objectives are to: 1) dissect the motor-based protein complexes in the sperm manchette that are essential for sperm tail formation, 2) establish an...
This $245,619 Project Grant was awarded on September 30, 2024 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will fund research at the University of Utah to investigate the relationship between genome mutagenesis, fertility, and health in fertile and infertile men. Specifically, the research will use advanced DNA sequencing techniques to examine germline and somatic mutation...
This federal Project Grant award of $157,000 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to reveal how the protein ASZ1 recruits PIWI proteins to the intermitochondrial cement (IMC) structure for PIRNA biogenesis in male germ cells. The project aims to uncover the essential protein interactions at IMC and define their roles in IMC construction, PIRNA...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $147,486 to support research investigating the role of the protein KIF2C in regulating the microtubule cytoskeleton during the oocyte-to-embryo transition in zebrafish. The award aims to determine how KIF2C controls microtubule organization during oocyte maturation and egg activation, and to link...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $248,999.00 to Colorado State University to conduct research on the mechanisms of temperature-sensitive meiotic chromosome structures in male infertility. The primary objectives of this 3-year project are to: 1) investigate how differences in the organization and composition of the synaptonemal...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $271,728 in funding to the Whitehead Institute for Biomedical Research to uncover the molecular mechanisms that initiate and maintain germ cell identity. The research aims to: (a) uncover mechanisms that repress the somatic program, allowing the primordial germ cell (PGC) program to develop, and (b)...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research to investigate the molecular mechanisms underlying fertilization and egg activation in the model organism Caenorhabditis elegans. The $133,207 award, with an effective date of August 9, 2024 and an end date of July 31, 2026, will fund the research aims of the Principal Investigator at Rutgers, The State University. The...
This Project Grant award for $483,640 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to determine the roles of autophagy in gametogenesis (sexual reproduction) in the yeast Saccharomyces cerevisiae. The research aims to investigate three key directions: 1) how autophagy promotes gametogenesis, 2) how gametogenesis regulates autophagy, and 3) how stresses affect autophagy and gametogenesis...