Project Grant R00HD108420
Award Date
9/1/24
Completion Date
7/31/27
Dollars Obligated
$249K
Federal Agency
National Institute of Child Health and Human Development
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Nashville, TN 37203, USA
Similar Awards
This $635,254 federal Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop and test the use of extracellular vesicles to deliver the anti-inflammatory cytokine interleukin-10 (IL-10) as an intervention to delay preterm birth. The award period runs from August 1, 2024 to May 31, 2029. The key objectives of this project are to: 1) determine the...
This federal Project Grant award of $2,060,562 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to test the efficacy of a novel synthetic progestin, R5020, in reducing inflammation and preventing preterm labor in an animal model of intrauterine infection and inflammation (IUI). The research will utilize a rhesus macaque model of IUI, with two key aims: 1) to...
This Project Grant award, issued by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $219,592 in funding to the University of Nevada, Reno to develop novel designed multi-ligand (DML) drugs as potential tocolytics for the treatment of preterm labor. The key goals of this research are to generate DML drug candidates that can target dysregulated pathways in preterm myometrium to...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of a novel, uterine-targeted drug delivery system to treat preterm labor. The $126,568 award to Vanderbilt University will fund research to: 1) optimize the physical-chemical parameters of the drug delivery system to maximize encapsulation and antibody targeting efficiency, and 2)...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $545,686 to The Washington University to conduct research on the role of T cells and the cytokine interleukin-9 (IL-9) at the maternal-fetal interface in preterm labor and birth. The project aims to elucidate the mechanisms by which IL-9 promotes preterm labor and birth, define the impact of maternal IL-9 on fetal...
This $178,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to develop an early life phenotyping framework for very preterm infants. The research aims to create 'perinatal phenotypes' by integrating variables such as reason for preterm birth, intrapartum care, and neonatal presentation, and then determine how these phenotypes contribute to...
The National Institute of Child Health and Human Development (NICHD) awarded a $424,875 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Maryland, Baltimore (UMB) to investigate the role of placental serum amyloid A (SAA) isoforms in response to sub-chronic maternal inflammation and explore whether inhibition of the SAA2 isoform using small interfering RNA (siRNA) can alleviate preterm birth and adverse fetal outcomes. The project aims...
This federal Project Grant award of $139,446.00 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to evaluate the mechanisms by which cell-free fetal DNA (cfDNA) signaling promotes the onset of labor. The award recipient, Mayo Clinic, will conduct research to determine if inhibiting the cGAS/STING pathway can reduce maternal CD14+ monocyte activation and the subsequent...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate the use of a selective TNFR2 blockade to prevent infertility associated with chlamydia pelvic inflammatory disease (PID). The $335,000 award, effective August 1, 2024 through July 31, 2026, will enable the establishment of a humanized TNFA/TNFR1/TNFR2 (HTNF) mouse model to...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $414,026 to Childrens Hospital Medical Center in Cincinnati, Ohio to conduct research on the mechanisms by which maternal interleukin-10 (IL-10) restricts fetal emergency myelopoiesis. The goal is to understand how maternal inflammation during pregnancy impacts placental function and...