Project Grant R21HD113862
- The Applied Research Foundation of West Virginia received a $444,000 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research program) to study the effects of stress on Chlamydia infections in a mouse model. The research aims to define the mechanisms by which stress may suppress the immune system and increase the intensity of Chlamydia genital infection and its associated immunopathologies. Key aspects of the project...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $404,570 to the University of California, Davis under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 13, 2026, with completion targeted for January 31, 2028. This Project Grant supports research aimed at identifying and validating target antigens for Chlamydia trachomatis vaccine development. The research addresses a significant public health need, as C....
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded the University of California, San Diego a $566,573 Project Grant effective August 1, 2025, through July 31, 2030, under the Child Health and Human Development Extramural Research program (CFDA 93.865). This award supports a randomized-controlled trial designed to evaluate point-of-care screening and treatment for Chlamydia trachomatis (CT) infection among asymptomatic pregnant women in...
- Federal Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $156,000 Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded on July 14, 2025, with an ultimate completion date of June 30, 2027. The award supports biomedical research focused on characterizing homotypic fusion mechanisms in Chlamydia muridarum, a surrogate model for understanding...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $170,753 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 14, 2025, with a completion date of November 30, 2026. This award funds biomedical research designed to elucidate the molecular mechanisms by which Chlamydia trachomatis (CT), the most common sexually transmitted...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Kentucky Research Foundation a Project Grant totaling $423,500 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 1, 2025, through June 30, 2027. This research project investigates the functional roles of chlamydial polymorphic membrane proteins (PMPs), specifically PMPI, during the infectious cycle of Chlamydia trachomatis. The...
- Federal Grant Award Summary The University of Tennessee Health Science Center (UTHSC) received a $782,795 Project Grant award dated June 17, 2025, from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project, "Regulation of Chlamydial Divisome Assembly," focuses on investigating the mechanisms underlying cell division in Chlamydia trachomatis, the leading bacterial cause of sexually...
- Federal Grant Award Summary Rutgers University's School of Nursing received a $445,250 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 6, 2025, with a completion date of July 31, 2027. The grant funds research to develop and validate a mouse model of congenital syphilis (CS) caused by Treponema pallidum, addressing a significant public health gap. The project will...
- Summary Creighton University received a $159,600 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 15, 2025, through July 31, 2027. The award supports research aimed at characterizing how interferon epsilon (IFNE), a non-canonical type I interferon, protects host cells against Trichomonas vaginalis (TV), the parasitic causative agent of trichomoniasis—the most...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Virginia $717,952 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct investigator-initiated biomedical research on Chlamydia trachomatis pathogenesis. The project, initiated February 9, 2026, and extending through January 31, 2031, focuses on identifying and characterizing essential chlamydia-specific factors to advance the development...
TNFR2 BLOCKADE PREVENTION OF STI INFERTILITY - PROJECT SUMMARY CHLAMYDIA TRACHOMATIS (CT) IS THE MOST COMMON BACTERIAL SEXUALLY TRANSMITTED INFECTION WORLDWIDE, AND PUBLIC HEALTH MEASURES INCLUDING TEST-AND-TREAT STRATEGIES HAVE BEEN INEFFECTIVE AT CURBING INCIDENCE AND PREVALENCE. AS A CONSEQUENCE, CT PELVIC INFLAMMATORY DISEASE AND SEQUELAE OF ECTOPIC PREGNANCIES AND INFERTILITY CONTINUE TO BE IMPORTANT MEDICAL ISSUES. CURRENTLY THERE IS NO THERAPY THAT PREVENTS PID-ASSOCIATED INFERTILITY. THE CENTRAL HYPOTHESES OF THE GRANT BASED ON CHLAMYDIA MURIDARUM (CM) MOUSE MODEL DATA IS THAT SELECTIVE TNFR2 BLOCKADE WILL PREVENT CHLAMYDIA PID ASSOCIATED IMMUNOPATHOLOGY AND INFERTILITY. ENABLING THIS INVESTIGATION ARE A HUMANIZED INHIBITORY ANTI-HUMAN TNFR2 MONOCLONAL ANTIBODY DEVELOPED BY THE JOHNSON LAB AND A NEW HUMANIZED TNFA/TNFR1/TNFR2 (HTNF) MOUSE MODEL DEVELOPED BY BIOCYTOGEN. AIM #1: TO ESTABLISH A HTNF MOUSE BREEDING COLONY AND COMPARE CM BACTERIAL SHEDDING AND IMMUNOPATHOLOGY SCORES IN HTNF MICE WITH WILD TYPE C57BL/6 MICE BRED IN THE SAME FACILITY. AIM #2: USE GENE SYNTHESIS TECHNOLOGY TO RAPIDLY GENERATE SUBCLASS VARIANTS OF THE SUCCESSFULLY HUMANIZED RAT ANTI-HUMAN TNFR2 26C09 MONOCLONAL ANTIBODY TO INVESTIGATE THEIR INHIBITORY ACTIVITY IN HUMAN PBMC ACTIVATION ASSAYS AND DETERMINE EFFICACY OF MOUSE EQUIVALENTS FOR PREVENTING IMMUNOPATHOLOGY IN THE CM-HTNF MOUSE MODEL.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.6k | 7/29/25 | ||
| Not listed | $335.0k | 8/1/24 |