The National Institute of Child Health and Human Development (NICHD) awarded a $414,026 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Childrens Hospital Medical Center in Cincinnati, Ohio. The grant will fund research to determine the mechanism by which maternal interleukin-10 (IL-10) restricts fetal emergency myelopoiesis, with the goal of improving neonatal immune function and outcomes. The research will investigate how maternal inflammation impacts placental serotonin synthesis, and how this signal regulates fetal hematopoietic stem and progenitor cells either directly or indirectly. The project aims to identify potential therapeutic targets along this cascade to boost neonatal immunity. The award has a performance period from September 1, 2024 through August 31, 2027.
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