This $635,254 federal Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop and test the use of extracellular vesicles to deliver the anti-inflammatory cytokine interleukin-10 (IL-10) as an intervention to delay preterm birth. The award period runs from August 1, 2024 to May 31, 2029. The key objectives of this project are to: 1) determine the...
The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...
This Project Grant award of $248,999 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to identify effective therapeutic agents for managing infection-induced preterm labor (III-PTL) and protecting against fetal inflammation. The key activities under this award include: 1) Optimizing a high-throughput screening assay to measure changes in pro-inflammatory cytokines...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting research to develop a targeted, placenta-tropic lipid nanoparticle (LNP) platform for the delivery of mRNA therapeutics to treat pre-eclampsia, a serious pregnancy complication. The $349,375 award will fund the evaluation of a large library of novel ionizable LNPs for placental tropism,...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $414,026 to Childrens Hospital Medical Center in Cincinnati, Ohio to conduct research on determining the mechanism by which maternal interleukin-10 (IL-10) restricts fetal emergency myelopoiesis, with the goal of improving neonatal outcomes. The research aims to identify the IL-10-responsive...
The National Institute of Child Health and Human Development (NICHD) awarded a $481,250 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Oregon Health & Science University (OHSU). The grant, awarded on September 1, 2024, will support research to investigate the mechanisms of neuroinflammation and perinatal brain injury associated with intrauterine infection by the bacteria Ureaplasma parvum. Specifically, the project aims to assess...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $132,779 to Yale University to study the role of TLR7/8-activating microRNAs in driving fetal inflammatory response syndrome and preterm birth. The key objectives are to determine if fetal membrane/amniotic fluid-derived exosomes containing these microRNAs mediate sterile fetal inflammation, if...
This $2,004,633 Project Grant, awarded on September 17, 2024 by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 Child Health and Human Development Extramural Research, supports research on dysregulated RNA metabolism and its role in maternal diabetes-induced neural tube defects (NTDs). The research aims to determine how maternal diabetes represses miR-322 expression, upregulates the RNA binding protein RBM47, and stabilizes the long non-coding RNA NEAT1,...
The National Institute of Child Health and Human Development (NICHD) awarded a $431,750 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Rutgers, The State University of New Jersey, to investigate how the cytokine interleukin-6 (IL-6) affects the proliferation, specification and gene expression of human and mouse secondary neural progenitor cells. The goal is to establish IL-6 as a key target for intervention to prevent neurodevelopmental disorders like...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA program 93.865, "Child Health and Human Development Extramural Research," provides $430,031.00 to evaluate the role of DNA methylation changes in very early preterm birth. The grant, awarded to Harvard T.H. Chan School of Public Health, will support research activities focused on understanding the complex biological mechanisms underlying preterm birth, a critical public...