Project Grant R01AI184481

Award Date 8/17/24
Completion Date 6/30/29
Dollars Obligated $1.1M
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
St. Louis, MO 63110, USA
Similar Awards
This federal Project Grant award of $219,456 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to understand how sterile inflammation at the maternal-fetal interface impacts the developing fetal immune system in a non-human primate model. The research aims to test the hypotheses that 1) injecting the clotting agent Tisseel into the maternal-fetal interface leads to placental inflammation, and 2) this...
This Project Grant award of $248,999 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to identify effective therapeutic agents for managing infection-induced preterm labor (III-PTL) and protecting against fetal inflammation. The key activities under this award include: 1) Optimizing a high-throughput screening assay to measure changes in pro-inflammatory cytokines...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,112,004 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant, effective September 1, 2024 through July 31, 2029, will support research to define the mechanistic features of Interleukin-27 (IL-27) signaling at the maternal-fetal interface that...
The National Institute of Child Health and Human Development (NICHD) awarded a $2,060,562 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of California, Los Angeles (UCLA) to conduct research on the prevention of preterm labor and fetal inflammation. The award will support a collaborative multi-disciplinary team at UCLA that will use advanced immunology, genomics/proteomics, and neuroscience approaches to investigate a...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,999,774 to the Regents of the University of Minnesota to conduct research focused on understanding how maternal microbial exposure fundamentally shapes the CD8 T cell population at the maternal-fetal interface. The key objectives are to investigate the regulation of CD8 T cell tolerance and host immune defense...
This Project Grant award of $857,346 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the Fred Hutchinson Cancer Center to study metabolite- and cytokine-mediated signals that control human CD8 T cell responses in tissues. The research aims to define the balance of activating and inhibitory signals present in healthy and acutely infected human tissues, which is relevant to understanding immune...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, provides $205,999 over 5 years to support a research program focused on understanding maternal-fetal immune interactions and the potential impact of environmental exposures on susceptibility to infection during pregnancy. The primary goal is to develop a cohort of young investigators with the skills to conduct high-quality...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is supporting research to investigate the role of T cells in promoting post-acute memory deficits after COVID-19 infection in mice. The $107,995 award to The Washington University, which runs from July 2025 to June 2027, will fund a study to determine how pathogenic CD4+ T cells are recruited to the central nervous...
This $649,053 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research by The Washington University to investigate the role of Ly49 family receptors on CD8 T cells. The central hypothesis is that immunization expands the sub-population of CD8 regulatory T cells (Tregs) that can resolve immune responses, and that Ly49 and the transcription factor Helios...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $562,500.00 to The Salk Institute for Biological Studies to investigate the functions of specialized intestinal T cells, called intraepithelial lymphocytes (IELs), that are recruited to the mammary gland during lactogenesis. The goal is to understand how these entero-mammary IELs promote maternal-offspring...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA 93.855 - Allergy and Infectious Diseases Research, is funding research to investigate the role of T cells and the cytokine IL-9 at the maternal-fetal interface in preterm labor and birth. The $1,096,566 award to Washington University aims to elucidate the mechanisms by which IL-9 promotes preterm birth, define the impact on offspring, and identify new T cell subtypes contributing to preterm labor in humans. The project leverages advanced mouse models, imaging mass cytometry, spatial transcriptomics, and single-cell RNA sequencing of human placental samples. Washington University has sub-awarded $250,159 to Indiana University, led by Co-Investigator Dr. Mark Kaplan, to contribute expertise in IL-9 biology and T cell immunity at the maternal-fetal interface. This innovative fusion of immunology and omics approaches seeks to unveil non-infectious causes of preterm birth and identify potential preventative treatments, such as vitamin D supplementation.

Generated 8/5/25, 4:42 AM