This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA 93.855 - Allergy and Infectious Diseases Research, is funding research to investigate the role of T cells and the cytokine IL-9 at the maternal-fetal interface in preterm labor and birth. The $1,096,566 award to Washington University aims to elucidate the mechanisms by which IL-9 promotes preterm birth, define the impact on offspring, and identify new T cell subtypes contributing to preterm labor in humans. The project leverages advanced mouse models, imaging mass cytometry, spatial transcriptomics, and single-cell RNA sequencing of human placental samples. Washington University has sub-awarded $250,159 to Indiana University, led by Co-Investigator Dr. Mark Kaplan, to contribute expertise in IL-9 biology and T cell immunity at the maternal-fetal interface. This innovative fusion of immunology and omics approaches seeks to unveil non-infectious causes of preterm birth and identify potential preventative treatments, such as vitamin D supplementation.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $550.9k | 6/24/25 | ||
| Not listed | $545.7k | 8/16/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
WU250159S | Trustees Of Indiana University | Project Grant R01AI184481 | $21.3k | 10/11/24 |