Project Grant R00EY034881
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $595,302 project grant to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, for the period of April 1, 2025 to March 31, 2030. The project aims to investigate how glucose and lactate support photoreceptor health and function in order to develop new treatment strategies to prevent vision loss. Specifically, the researchers will determine whether the retinal...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $306,814 to Piximune, Inc. to develop an antibody-based, gene-agnostic treatment for inherited retinal degeneration, such as retinitis pigmentosa. The proposed approach aims to augment natural mechanisms that eliminate toxic cellular debris from dead and dying photoreceptor cells, thereby protecting surrounding functional cells and preventing secondary retinal damage independent of the causal...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $475,442 to the University of California, Los Angeles (UCLA) to conduct research focused on understanding the mechanisms underlying the ingestion of photoreceptor outer segment tips by the retinal pigment epithelium (RPE). The research aims to investigate the dynamic actin polymerization and trogocytosis process involved in this essential cellular function, as well as the daily timing of outer...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, provides $385,000.00 in funding to Wayne State University to conduct research on genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research aims to understand, prevent, and treat vision-related conditions and diseases, a focus area of NEI's Vision Research federal grant program (CFDA 93.867). The study will compare...
- The federal Project Grant award of $249,000.00 from the National Eye Institute (NEI) under the Vision Research grant program (CFDA 93.867) will support research at the University of Maryland, Baltimore (UMB) to elucidate unique spectral-temporal fluorescence signatures to determine stratification and redistribution of intracellular retinal pigment epithelial (RPE) cell pigment granules. The research aims to provide fundamental insight into the connection between retinal pigment redistribution...
- This federal Project Grant award of $462,072 from the National Eye Institute's Vision Research program (CFDA 93.867) supports research at Tufts Medical Center to investigate the metabolic basis of retinopathy of prematurity (ROP) and potential treatments using anaplerotic substrates. The research aims to understand how hyperoxia exposure in premature infants impacts retinal neurovascular development and ROP, and evaluates the role of maternal nutrition, specifically medium-chain fatty acids,...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $144,200 Project Grant to Pennsylvania State University's Milton S. Hershey Medical Center. The grant, effective June 1, 2025 through November 30, 2027, will fund research to characterize the molecular mechanisms underlying increased levels of the protein REDD1 in the retina due to diabetes, and explore alternative intervention strategies for preventing retinal complications caused by...
- The National Eye Institute (NEI) awarded a $437,310 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Rochester to conduct research on the molecular and physiological mechanisms of inner retinal remodeling in retinal degeneration. The research aims to elucidate the mechanisms behind genetic, morphological, and physiological changes in retinal ganglion cells that lead to decreased signal-to-noise ratio and corruption of retinal circuits, with the...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $431,750 Project Grant to the University of Louisville to study the role of neurexin proteins in retinal structure and function. The grant, effective from September 1, 2025 to August 31, 2027, aims to 1) determine the function of three neurexin genes and their isoform-specific expression patterns within the retina, and 2) characterize the cell-type-specific expression of neurexin isoforms...
- This $427,625 Project Grant awarded by the National Eye Institute's Vision Research program on September 1, 2025 will support research to investigate the interplay between debris/dying cell clearance by specific retinal phagocytes and the potential for improving tissue healing in oxygen-induced retinopathy (OIR). The research, to be conducted by The Washington University, aims to determine whether cell-type specific expression of a chimeric efferocytosis (CHEF) receptor in Müller cells versus...
This National Eye Institute Project Grant award, under the Vision Research federal grant program (CFDA 93.867), provides $248,909.00 to Emory University to conduct research focused on understanding changes to metabolism during the progression of photoreceptor degeneration in retinitis pigmentosa (RP). The key goals are to determine how the rate of metabolism changes with RP disease stage and identify metabolites that increase oxygen consumption by the retinal pigment epithelium (RPE)-choroid. This 3-year research project, running from September 1, 2025 to August 31, 2028, aims to provide critical insights into RP-related metabolic disruptions that could inform strategies to protect photoreceptors and prevent vision loss in RP patients, regardless of the underlying genetic mutation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $248.9k | 8/7/25 |